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RNA-sequencing of fibrolamellar carcinoma (FLC) cell line treated with miR-375 mimic

ABSTRACT: RNA-sequencing of fibrolamellar carcinoma (FLC) cell line treated with miR-375 mimic

PROVIDER: PRJNA516900 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8483040_1.fastq.gz	Fastqsanger.gz
	SRR8483040_2.fastq.gz	Fastqsanger.gz
	SRR8483041_1.fastq.gz	Fastqsanger.gz
	SRR8483041_2.fastq.gz	Fastqsanger.gz
	SRR8483042_1.fastq.gz	Fastqsanger.gz

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RNA-sequencing of fibrolamellar carcinoma (FLC) cell line treated with miR-375 mimic

Project description:Fibrolamellar carcinoma (FLC) is a rare liver cancer. Expression of miR-375 is significantly lost in primary FLC tumors compared to non-malignant liver. Here, we treated a FLC cell line with miR-375 mimic or scramble control to determine the function of miR-375 in FLC.

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Multi-omic analysis of microRNA-mediated regulation reveals a proliferative axis involving miR-10b in fibrolamellar carcinoma

Project description:Fibrolamellar carcinoma (FLC) is an aggressive liver cancer with low survival rates and no standard-of-care. The vast majority of FLC patients carry a causative somatic mutation that leads to the gene fusion, DNAJB1-PRKACA. To work toward novel therapeutic strategies, it is important to understand the mechanisms underlying FLC etiology and progression. To that end, in this study, we analyzed a large sample cohort (52 patients) using multiple genome-scale assays to define genes subject primarily to post-transcriptional regulation by microRNAs. These studies revealed a candidate master microRNA regulator in FLC, miR-10b. Functional experiments in cells established from a patient-derived xenograft model revealed that miR-10b contributes to FLC cell metabolic health and proliferation.

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Project description:A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 5 mixed fibrolamellar carcinoma (m-FLC), 17 pure fibrolamellar carcinoma (p-FLC), 7 hepatocelluar carcinoma arising in non-cirrhotic liver (nc-HCC) and 10 non-tumoral livers (NL).

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CDK7 is a novel therapeutic vulnerability in Fibrolamellar cancer

Project description:To identify targets in Fibrolamellar cancer (FLC), we introduced the FLC driver gene mutation (DNAJB1-PRKACA) into HepG2 cells to engineer FLC cell lines. We then performed gene expression profiling analysis using data obtained from RNA-seq of 6 different cell samples from HepG2, H33 (FLC cell line) and H12 (FLC cell line)

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GENOMIC ANALYSIS OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA REVEALS A UNIQUE MOLECULAR PROFILE

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