Project description:Loss of SLX4IP elicits the metastatic outgrowth of nonmetastatic breast cancer cells by activating Wnt signaling to induce telomere maintenance mechanism switching We sought to assess genome-wide transcriptomic profiles governed by loss of SLX4IP expression in latent D2.OR breast cancer cells
Project description:SLX4IP mediates Hedgehog signaling through isoform-specific SUMOylation of GLI1 We sought to assess genome-wide transcriptomic and signaling changes induced by loss of SLX4IP in D2.OR breast cancer cells, which identified the Hedgehog pathways as being significantly disrupted by SLX4IP depletion