Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rattus norvegicus breed:Sprague Dawley rats

ABSTRACT: HR and LR rats exome sequencing

PROVIDER: PRJNA521139 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8541840.fastq.gz	Fastqsanger.gz
	SRR8541850.fastq.gz	Fastqsanger.gz
	SRR8541841.fastq.gz	Fastqsanger.gz
	SRR8541851.fastq.gz	Fastqsanger.gz
	SRR8541842.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Aversion to Desflurane and Isoflurane in Sprague-Dawley Rats (Rattus Norvegicus).

Project description:Carbon dioxide and isoflurane are widely used for killing rats, yet may not truly achieve "euthanasia", because they elicit aversion. The inhalant anesthetic desflurane is faster acting than isoflurane, representing a potential refinement. Using an aversion-avoidance paradigm, 24 rats were exposed to isoflurane or desflurane (n = 12 per group) at initial exposure. Fourteen rats were then re-exposed to isoflurane or desflurane (n = 7 per group), after a 7 days washout period. Initial exposure: time to recumbency was faster for desflurane than isoflurane (p = 0.0008, 95% CI [-12.9 to 32.6 s]), with 9/12 and 6/12 rats becoming recumbent, respectively. At initial exposure, there was no difference between groups in time to withdrawal (p = 0.714). At re-exposure, all rats withdrew and no rats became recumbent. Time to withdrawal at re-exposure did not differ between treatment groups (p = 0.083). Compared to initial exposure, time to withdrawal during re-exposure was similar for isoflurane (p = 0.228) and faster with desflurane (p = 0.012, 95% CI [19.1 to 49.5 s]). Isoflurane and desflurane are similarly aversive, with aversion increasing at re-exposure. The shorter time from exposure to recumbency with desflurane indicates that any distress is of a shorter duration when compared with isoflurane.

| S-EPMC7341512 | biostudies-literature

Rattus norvegicus breed:Sprague-Dawley rats

Project description:Effects of desalinated seawater with excessive boron on reproductive health of male rats

| PRJNA1020995 | ENA

Rattus norvegicus breed:Sprague Dawley

Project description:Genetic characterization of Sprague Dawley rats

| PRJNA779552 | ENA

Rattus norvegicus strain:Sprague-Dawley rats

Project description:Transcriptome of Sprague-Dawley rats

| PRJNA517238 | ENA

Rattus norvegicus breed:Sprague Dawley

Project description:16SrRNA sequencing of oral and intestinal microbiome in psychologically stressed rats

| PRJNA814321 | ENA

Pre-warming following premedication limits hypothermia before and during anesthesia in Sprague-Dawley rats <i>(Rattus norvegicus)</i>.

Project description:In humans and other mammals, general anesthesia impairs thermoregulation, leading to warm core blood redistributing to the periphery. This redistribution is an important contributor to hypothermia that can be reduced with pre-warming before anesthesia. Additionally, sedation following premedication has been associated with hypothermia in dogs. In a prospective, randomized, cross-over study, 8 adult male and female rats (weighing 388 to 755 g) were sedated with intramuscular ketamine-midazolam-hydromorphone, then placed in an unwarmed cage or warmed box for 14 minutes, followed by 30 minutes of isoflurane anesthesia with active warming. Core body temperature was monitored throughout. After sedation, warmed rats gained 0.28°C ± 0.13°C and unwarmed rats lost 0.19°C ± 0.43°C, a significant difference between groups (P = 0.004). After anesthesia, warmed rats maintained higher core temperatures (P < 0.0001) with 2/8 and 6/8 of warmed and unwarmed rats becoming hypothermic, respectively. Pre-warming during sedation and active warming during general anesthesia is effective in minimizing hypothermia.

| S-EPMC7995546 | biostudies-literature

Rattus norvegicus strain:Sprague-Dawley rats

Project description:Rattus norvegicus strain:Sprague-Dawley rats Genome sequencing

| PRJNA686507 | ENA

Rattus norvegicus breed:Sprague Dawley

Project description:Transcriptome analysis of diet-induced metabolic syndrome rats treated with ellagitannin geraniin

| PRJNA431835 | ENA

Rattus norvegicus breed:Sprague-Dawley

Project description:Transcriptomic analyses of DRG and dorsal spinal cord of Bdnf+/- and Bdnf / rats

| PRJNA525444 | ENA

Rattus norvegicus strain:Sprague-Dawley rats

Project description:Rattus norvegicus strain:Sprague-Dawley rats Raw sequence reads