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ABSTRACT: Circular RNA profile of steroid-induced osteonecrosis of the femoral head

PROVIDER: PRJNA522627 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8580924_1.fastq.gz	Fastqsanger.gz
	SRR8580924_2.fastq.gz	Fastqsanger.gz
	SRR8580925_1.fastq.gz	Fastqsanger.gz
	SRR8580925_2.fastq.gz	Fastqsanger.gz
	SRR8580926_1.fastq.gz	Fastqsanger.gz

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MicroRNAs expression different in Serum between Trauma-induced osteonecrosis of the femoral head (TIONFH) and healing patients

Project description:We recently showed that microRNA different profile from Trauma-induced osteonecrosis of the femoral head (TIONFH) and healing patients.

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Identification of Potential Biomarkers for Improving the Precision of Early Detection of Steroid-induced Osteonecrosis of the Femoral Head

Project description:Early diagnosis and prompt treatment are the key to prevent collapse and delay Steroid-induced Osteonecrosis of the Femoral Head(SONFH) progression.The aim of this study was to identify potential biomarkers for the diagnosis of SONFH, so to improve the efficiency of early diagnosis. Microarray analysis based on the 30 SONFH patients and 10 non-SONFH patients(following steroid administration) was performed to screen SONFH-related genes.

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Single-Cell RNA Sequencing Reveals Distinct Cellular and Molecular Features of Steroid-Induced Osteonecrosis of the Femoral Head Compared to Alcohol-Induced Osteonecrosis and Hip Osteoarthritis

Project description:Osteonecrosis of the femoral head (ONFH) remains a devastating complication of glucocorticoid therapy and alcohol abuse, yet the pathophysiology is poorly understood. Using single-cell RNA sequencing, we analyzed femoral head specimens from patients undergoing total hip arthroplasty due to steroid-induced ONFH, alcohol-induced ONFH, or hip osteoarthritis (OA). Our comprehensive analysis across conditions revealed etiology-specific cellular compositions and transcriptional profiles. Steroid-induced ONFH demonstrated a distinctive immunological signature characterized by a neutrophil-predominant, elevated innate-to-adaptive immune cell ratio compared to alcohol-induced ONFH or OA. T cell analysis revealed impaired maturation in steroid-induced ONFH, with abundant naïve T cells but reduced mature CD4+ T cells and CD4+ memory T cells compared to both alcohol-induced ONFH and OA. In addition, compared to alcohol-induced ONFH, steroid-induced ONFH was associated with an increase in exhausted/dysfunctional CD8+ T cells which suggests an impaired response to stress and reflects chronic immune dysfunction. Within stromal cell populations, steroid-induced ONFH demonstrated an increase in pericytes, endothelial cells, and mesenchymal cell with osteogenic features as compared to both alcohol-induced ONFH or OA. These findings collectively reveal novel cellular mechanisms underlying steroid-induced ONFH which may contribute to further investigation of etiology-specific pathogenesis and treatment strategies.

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Biomarker for steroid-induced osteonecrosis of the femoral head

Project description:Early diagnosis is crucial to increase the chances of conservation treatment for patients with steroid-induced osteonecrosis of the femoral head (SIONFH). This study aimed to identify serum peptides as potential biomarkers to diagnose SIONFH.

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Analysis of components of Buxuetongluo Pills by LC-MS/MS

Project description:Buxue tongluo Pills(BTP) are a pill commonly used to treat osteonecrosis of the femoral head, but its composition and mechanism are unclear. As a result, we analyzed the components of BTP by LC-MS/MS.

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Exploring changes in miRNA expression levels in bone marrow mesenchymal stem cells under dexamethasone treatment using miRNA sequencing

Project description:In the progression of glucocorticoids (GCs) induced osteonecrosis of the femoral head (ONFH), miRNAs have important regulatory role and is involved in many biological processes. In this current study, we detected the expression levels of miRNA in bone marrow mesenchymal stem cells (BMSCs) after 48 hours of dexamethasone intervention and further explored the role of key miRNA in a GCs induced ONFH rat model.

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Gene expression of rat BMSCs stimulated with or without dexamethasone

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