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ABSTRACT: Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

PROVIDER: PRJNA524398 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR8788710.fastq.gz	Fastqsanger.gz
	SRR8816330.fastq.gz	Fastqsanger.gz
	SRR8816321.fastq.gz	Fastqsanger.gz
	SRR8816331.fastq.gz	Fastqsanger.gz

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Project description:Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

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Project description:Single cell RNA Sequencing of term Umbilical cord blood mononuclear cells

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Proteomic analysis of exosomes isolated from human umbilical cord serum by mass spectrometry and preliminary study of their biological activities in cultured hepatocellular carcinoma cell lines

Project description:Exosomes are membranous extracellular vesicles 50–100 nm in size and are involved in cellular communication via the delivery of proteins, lipids, and RNAs. Emerging evidence shows that exosomes play a critical role in cancer. A recent study has revealed that maternal and umbilical cord serum-derived exosomes may enhance endothelial cell proliferation and migration. However, the role of exosomes isolated from the human umbilical cord in cancer development has not been investigated. To explore the potential differences in the composition and function of proteins from umbilical cord blood exosomes and maternal serum exosomes, we conducted a proteomic analysis of exosomes by mass spectrometry and bioinformatics analysis. We used the CCK-8 assay and flow cytometry to study the biological effects of umbilical serum exosomes on hepatoma cells. Our study shows that umbilical cord blood is enriched with proteins involved in ECM-receptor interactions, which may be closely related to cell metastasis and proliferation. Our findings indicate that exosomes derived from human umbilical serum can suppress the viability of hepatoma cells and may induce apoptosis of hepatoma cells. This evidence suggests that umbilical cord serum-derived exosomes may be potential leads for the development of biotherapy for liver cancer.

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