SHP2 Blockade Sensitizes Metastatic Triple Negative Breast Cancer to PI3K Inhibition
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA526210 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR8699420_1.fastq.gz | Fastqsanger.gz | |||
| SRR8699420_2.fastq.gz | Fastqsanger.gz | |||
| SRR8699430_1.fastq.gz | Fastqsanger.gz | |||
| SRR8699430_2.fastq.gz | Fastqsanger.gz | |||
| SRR8699421_1.fastq.gz | Fastqsanger.gz |
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Project description:The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of a primary triple-negative breast tumor grown as xenografts in the presence or absence of SHP2 for 30 days.
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