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Does high fibre diet or acetate supplementation cause changes to DNA methylation in the heart or spleen?

ABSTRACT: Does high fibre diet or acetate supplementation cause changes to DNA methylation in the heart or spleen?

PROVIDER: PRJNA528947 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8782830.fastq.gz	Fastqsanger.gz
	SRR8782840.fastq.gz	Fastqsanger.gz
	SRR8782821.fastq.gz	Fastqsanger.gz
	SRR8782831.fastq.gz	Fastqsanger.gz
	SRR8782841.fastq.gz	Fastqsanger.gz

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Does high fibre diet or acetate supplementation cause changes to DNA methylation in the heart or spleen?

Project description:Mice were fed either a control diet, high fibre diet or a diet supplemented with acetate for 3 weeks. Heart (left ventricle) and spleen tissues were harvested for DNA methylation analysis.

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Expression data from fetal mouse lung from mothers fed high fibre or acetate

Project description:We used microarrays to detail the global programme of gene expression in the fetal lung late in gestation, from mothers that had been fed normal chow, high fibre, or acetate in the drinking water. The experiment was designed to examine the hypothesis that metabolites of the mother i.e. acetate could cross the placenta and influence gene transcription in the fetus. Diets used were "Normal chow" (NC) (8720310), or "High-fiber" (SF11-025) (Specialty feeds, Perth, Australia. Acetate (200 mM) was provided in the drinking water and refreshed three times per week. Gene expression in the lung may be affected by metabolites in utero. We examined whole lung of E21 fetuses from high-fiber fed mothers, normal chow fed mothers and acetate in drinking water fed mothers. Added fibre in the diet, or acetate in drinking water, would allow simple comparison with normal chow fed mothers, to determine whether fibre/acetate affected gene transcription in the fetal lung.

2015-06-29 | E-GEOD-69525 | biostudies-arrayexpress

Expression data from fetal mouse lung from mothers fed high fibre or acetate

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2006-06-27 | GSE5133 | GEO

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Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

Project description:Autism spectrum disorder (ASD) is a heterogenous neurodevelopmental disorder with complex pathophysiology including both genetic and environmental factors. Recent evidence demonstrates the gut microbiome and its resultant metabolome can influence brain and behavior and have been implicated in ASD. To investigate gene by microbiome interactions in a model for genetic risk of ASD, we utilize mutant mice carrying a deletion of the ASD-associated Shank3 gene (Shank3KO). Shank3KO have altered microbiome composition and function at baseline in addition to social deficits. Further depletion of the microbiome with antibiotics exacerbates social deficits in Shank3KO, and results in transcriptional changes in the frontal cortex. Supplementation with the microbial metabolite acetate leads to reversal of social behavioral phenotypes even in mice with a depleted microbiome, and significantly alters transcriptional regulation in the prefrontal cortex. These results suggest a key role for the gut microbiome and the neuroactive metabolite acetate in regulating ASD-like behaviors.

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Within and between-species transcript profiling during cotton fibre development

Project description:A gene expression profiling study on two major cotton species that are cultivated for fibre, Gossypium hirsutum (L.) and Gossypium barbadense (L.), at different stages during fibre development using a printed cDNA microarray was undertaken to identify potential candidate genes for manipulation to improve fibre quality. Keywords: Species comparison, development Three-condition experiment: 7, 11 and 21 day post anthesis. Biological replicates: 3, Two species compared at each condition: Gossypium.hirsutum and Gossypium.barbadense. One replicate per array, dye swap, one rep per array.

2010-05-16 | E-GEOD-10363 | biostudies-arrayexpress

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