Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Skeletal Muscle Transcriptomics

ABSTRACT: Skeletal Muscle Transcriptomics

PROVIDER: PRJNA532382 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8882180.fastq.gz	Fastqsanger.gz
	SRR8882190.fastq.gz	Fastqsanger.gz
	SRR8882200.fastq.gz	Fastqsanger.gz
	SRR8882210.fastq.gz	Fastqsanger.gz
	SRR8882220.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 53

Similar Datasets

Longitudinal skeletal muscle transcriptomics in WT mice

Project description:Longitudinal skeletal muscle transcriptomics in WT mice

| PRJNA886411 | ENA

Skeletal Muscle Transcriptomics

Project description:Healthy human skeletal muscle samples were processed and analyzed to infer age associated skeletal muscle changes.

2020-04-07 | GSE129643 | GEO

Skeletal muscle transcriptomics dissects the pathogenesis of Friedreich's Ataxia

Project description:Skeletal muscle transcriptomics dissects the pathogenesis of Friedreich's Ataxia

| PRJNA940990 | ENA

Transcriptomics analysis of skeletal muscle in humans with heart failure

Project description:Transcriptomics analysis of skeletal muscle in humans with heart failure

| PRJEB35460 | ENA

Transcriptomics analysis of skeletal muscle in type 2 diabetes patients

Project description:Transcriptomics analysis of skeletal muscle in type 2 diabetes patients

| PRJEB37684 | ENA

Bulk RNA transcriptomics of IIM muscle

Project description:We performed bulk RNA transcriptomics of skeletal muscle samples from patients with idiopathic inflammatory myopathies.

2024-10-11 | GSE260786 | GEO

Equine skeletal muscle transcriptomics

Project description:Equine skeletal muscle RNA-seq from samples taken at rest and post acute exercise.

| PRJEB35187 | ENA

Skeletal muscle specific overexpression of miRNA-1 impairs mechanical overload-induced skeletal muscle hypertrophy

Project description:MicroRNAs (miRNAs) are small, non-coding RNAs that play a critical role in regulating gene expression post-transcriptionally. Skeletal muscle-specific miRNAs, including miR-1, are important for skeletal muscle development and maintenance. In response to mechanical loading, skeletal muscle levels of miR-1 decrease by approximately 50%, suggesting a potential involvement in muscle hypertrophy. In the current investigation, we hypothesized that a reduction of miR-1 levels in response to mechanical loading would be necessary for skeletal muscle growth to occur. By significantly elevating miR-1 levels during the hypertrophic process via lentiviral delivery, we observed a blunted growth response in the plantaris muscle subjected to synergist ablation. A deeper RNA-based integrative analysis (transcriptomics and RNA eCLIP) indicates that miR-1 inhibits the expression of Itm2a and Melusin, two membrane-related proteins. While their exact mechanism in muscle hypertrophy is yet to be identified, our results suggest that miR-1-regulated membrane proteins are important for skeletal muscle hypertrophy.

2025-01-13 | GSE265946 | GEO

Yap regulates fatty acid oxidation in skeletal muscle [ATAC-seq]

Project description:The Hippo signalling pathway effector Yap positively regulates adult skeletal muscle mass. However, the biological processes that are modulated by Yap in skeletal muscle remain elusive. Using an integrated transcriptomics and proteomics approach, we define the transcriptional programme regulated by Yap in adult skeletal muscle and demonstrate that Yap is a regulator of metabolic substrate utilisation. Inhibition of Yap in mammalian skeletal muscle results in increased, but incomplete, oxidation of fatty acids and features of lipotoxicity. In line with these findings, we demonstrate that Yap abundance is reduced in the skeletal musculature of obese db/db mice, and in muscle biopsies from obese, insulin-resistant humans where YAP levels positively correlate with whole-body metabolic flexibility. Increasing Yap abundance in the striated muscle of db/db mice attenuated the accumulation of fat mass and development of hepatic steatosis. Our findings demonstrate a vital role for Yap in skeletal muscle as a mediator of metabolic substrate utilisation. Modulating Yap activity in skeletal muscle warrants consideration as part of comprehensive approaches to treat metabolic disease.

2021-02-18 | GSE144137 | GEO

Skeletal muscle specific overexpression of miRNA-1 impairs mechanical overload-induced skeletal muscle hypertrophy [RNA-Seq]

2025-01-13 | GSE265982 | GEO