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Drug combination of 17-AAG and Belinostat on MDA-MB-231 breast cancer cells

ABSTRACT: Drug combination of 17-AAG and Belinostat on MDA-MB-231 breast cancer cells

PROVIDER: PRJNA533241 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8921520_1.fastq.gz	Fastqsanger.gz
	SRR8921520_2.fastq.gz	Fastqsanger.gz
	SRR8921513_1.fastq.gz	Fastqsanger.gz
	SRR8921513_2.fastq.gz	Fastqsanger.gz
	SRR8921514_1.fastq.gz	Fastqsanger.gz

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Drug combination of 17-AAG and Belinostat on MDA-MB-231 breast cancer cells

Project description:Breast cancer is the most common cancer that threatens women's health. While the strategy of drug combination can help to reduce adverse effects and to overcome the resistance of clinical treatment of single drug. In this work, we report the synergetic effect between a HSP90 inhibitor 17-AAG and a HDAC inhibitor Belinostat, on the triple-negative breast cancer MDA-MB-231 cells. The RNA-Seq data analysis showed that the most over-represented KEGG pathways in the combination group came from migration or invasion related genes, which were not observed in the differentially expressed genes after the treatment of 17-AAG or Belinostat alone.

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Project description:The project profiled the expression patterns in hypoxia induced secretomes between MDA-MB-231 parental and MDA-MB-231 Bone Tropic (BT) breast cancer cell lines which have been previously generated by Massague and colleagues (Kang et al. Cancer Cell 2003).

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MDA-MB-231 cells: shMUC4 transfected vs. Control SCR

Project description:Identification of MUC4-associated expression of genes by comparing MUC4 knockdown (MDA-MB-231-shMUC4) and control (MDA-MB-231-SCR).

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Differentially expressed miRNAs in MDA-MB-231 over-expressing GATA3

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