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Peromyscus maniculatus

ABSTRACT: The North American deer mouse is a widespread rodent with numerous subspecies

PROVIDER: PRJNA53865 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	5-10_indel.vcf.gz	Vcf
	5-10_indel.vcf.gz.tbi	Vcf
	5-10_snps.vcf.gz	Vcf
	5-10_snps.vcf.gz.tbi	Vcf

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Peromyscus maniculatus

Project description:Peromyscus maniculatus (eastern deer mouse), mPerMan2

| PRJNA1257874 | ENA

Peromyscus maniculatus

Project description:Peromyscus maniculatus (eastern deer mouse) genomic and transcriptomic data

| PRJNA1257890 | ENA

Evaluation of Peromyscus leucopus Bone Marrow-Derived Macrophage Responses to Borrelia burgdorferi and Lipopolysaccharide

Project description:Currently, most tools utilized in host-pathogen interaction studies depend on the use of human or mouse (Mus musculus) cells and tissues. While these species have led to countless breakthroughs in our understanding of infectious disease, there are undoubtably important biological processes that are missed by limiting studies to these two vertebrate species. For instance, it is well-established that the most common North American rodent, the Peromyscus leucopus deermouse, has unique interactions with microbes, which likely shape its ability to serve as a critical reservoir for at numerous zoonotic pathogens—including a Lyme disease spirochete, Borrelia burgdorferi. In this work, we expand the immunological toolkit to study P. leucopus biology by performing the first differentiation of deermouse bone marrow to macrophages using P. leucopus M-CSF producing HEK293T cells.

2025-05-08 | GSE283617 | GEO

Deer mouse (Peromyscus sp.)

Project description:Peromyscus maniculatus (North American deer mouse) and Peromyscus leucopus (white-footed mouse). Raw sequence reads

| PRJNA494419 | ENA

Whole Transcriptome RNA-seq in Peromyscus maniculatus fibroblasts

Project description:Analysis of gene expression can be challenging, especially if it involves genetically diverse populations that exhibit high variation in their individual expression profile. Despite this variation though, it is conceivable that in the same individuals a high degree of coordination is maintained between transcripts that belong to the same signaling modules and are associated with related biological functions. To explore this further, we calculated the correlation in the expression levels between each of ATF4, CHOP (DDIT3), GRP94, DNAJB9 (ERdj4), DNAJ3C (p58IPK) and HSPA5 (BiP/GRP78) with the whole transcriptome in primary fibroblasts from deer mice following induction of endoplasmic reticulum (ER) stress. Since these genes are associated with different transducers of the unfolded protein response (UPR) we postulated that their profile, in terms of correlation of transcripts, reflects distinct UPR branches engaged and therefore different biological processes. Standard gene ontology analysis was able to predict major functions associated with the corresponding transcript, and of the UPR arm related to that, namely regulation of the apoptotic response by ATF4 (PERK arm) and the ER stress associated degradation for GRP94 (IRE1). BiP, being a global regulator of the UPR, was associated with activation of ER stress in a rather global manner. Pairwise comparison in the correlation coefficients for these genes’ associated transcriptome showed the relevance of selected genes in terms of expression profiles.

2019-05-18 | GSE131429 | GEO

Whole Transcriptome RNA-seq in Brain Tissue of Young and Old Peromyscus maniculatus and P. leucopus

Project description:Whole transcriptome RNA sequencing in brain tissue was generated to explore differences between young and old animals of two closely related species of deer mice (genus Peromyscus) that reportedly differ in their lifespans: P. leucopus that lives for up to 8 years and P. maniculatus that exhibits a lifespan of about 4 years.

2021-03-31 | GSE166394 | GEO

Peromyscus leucopus

Project description:The white-footed mouse is a rodent native to North America

| PRJNA53869 | ENA

Peromyscus maniculatus gut microbiome

Project description:Captivity and urbanization have distinct effects on the gut microbiome of deer mice (Peromyscus maniculatus)

| PRJEB51510 | ENA

Peromyscus californicus

Project description:The California mouse is a rodent native to north-western Mexico and southern California

| PRJNA53897 | ENA

Genomic variation in captive deer mouse (Peromyscus maniculatus) populations.

Project description:BackgroundDeer mice (genus Peromyscus) are the most common rodents in North America. Despite the availability of reference genomes for some species, a comprehensive database of polymorphisms, especially in those maintained as living stocks and distributed to academic investigators, is missing. In the present study we surveyed two populations of P. maniculatus that are maintained at the Peromyscus Genetic Stock Center (PGSC) for polymorphisms across their 2.5 × 109 bp genome.ResultsHigh density of variation was identified, corresponding to one SNP every 55 bp for the high altitude stock (SM2) or 207 bp for the low altitude stock (BW) using snpEff (v4.3). Indels were detected every 1157 bp for BW or 311 bp for SM2. The average Watterson estimator for the BW and SM2 populations is 248813.70388 and 869071.7671 respectively. Some differences in the distribution of missense, nonsense and silent mutations were identified between the stocks, as well as polymorphisms in genes associated with inflammation (NFATC2), hypoxia (HIF1a) and cholesterol metabolism (INSIG1) and may possess value in modeling pathology.ConclusionsThis genomic resource, in combination with the availability of P. maniculatus from the PGSC, is expected to promote genetic and genomic studies with this animal model.

| S-EPMC8438655 | biostudies-literature

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