Project description:Parental and AqR cells were obtained at diferent time-points (Day1 and Day 18). Total RNA was extracted and submitted for RNA-seq. Differential expression was observed between parental and AqR cells. AqR cells were derived from parental cells by adding inhibitor (CAY10566) every 3 days until cells became resistant (at about 3 weeks).
Project description:Parental and AqR cells were obtained. DNA was purified and submited for sequencing. Differential chromatin accessiblity was observed. AqR cells were derived from parental cells by adding inhibitor (CAY10566) every 3 days until cells became resistant (at about 3 weeks).
Project description:To investigate the transcriptinal alterations in RMC-4998 sensitive LU65 cells and cells that have acquired resistance to RMC-4998. The resistant cell lines of LU65 was generated following chronic treatment with RMC-4998. We then performed gene expression profiling analysis using data obtained from RNA-seq of parental and resistant lines.
Project description:RNA transcriptome sequencing analysis was performed in SNU-668 Erastin-resistant cells and SNU-668 parental cells, SNU-484 RSL3-resistant cells and SNU-484 parental cells
Project description:RNA sequencing data of paired parental and therapy resistant cancer cell lines. Parental cell lines are mostly established cell lines. Resistant cell lines were obtained through long term exposure of the parental cells to gradually increasing doses of cancer therapies. Samples include 7 parental and 10 derived resistant cell lines. Our aim was to assess whether the resistant cells had undergone Epithelial to Mesenchymal Transition upon resistance acquisition.
Project description:To determine the difference between MRTX849 parental and resistant cells in response to MRTX849 treatment, we used high-throughput next-generation sequencing technology to compare transcriptomics between parental and MRTX849-resistant MIA PaCa-2 cells that were cultured in the absence or presence of MRTX849 (1 uM, 4h).