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Global analyisis to study the bud27∆ and WT treated with rapamycin regarding to WT [RNA-seq]

ABSTRACT: Global analyisis to study the bud27∆ and WT treated with rapamycin regarding to WT [RNA-seq]

PROVIDER: PRJNA543471 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9079140.fastq.gz	Fastqsanger.gz
	SRR9079141.fastq.gz	Fastqsanger.gz
	SRR9079142.fastq.gz	Fastqsanger.gz
	SRR9079143.fastq.gz	Fastqsanger.gz
	SRR9079144.fastq.gz	Fastqsanger.gz

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Global analyisis to study the bud27∆ and WT treated with rapamycin regarding to WT [RNA-seq]

Project description:RNA extraction for global analyisis and sequencing, to study the bud27∆ mutant and WT treated with rapamycin regarding to WT.

2020-06-22 | GSE131389 | GEO

Genome-wide maps of Bud27 binding to the chromatin [ChIP-seq]

Project description:The goal of this study is to analyse genome-wide the binding profile of Bud27 prefoldin-like to the genes or other genomic regions in order to know which genes could be transcriptionally regulated by this protein and to elucidate the contribution of Bud27 to the transcription. Average normalised ChIP-seq signal for Bud27 prefoldin-like binding in a S.cerevisiae wild-type strain.

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RSC and Bud27 influences chromatin organization and alternative polyadenylation

Project description:The association of the RSC remodeler complex with the chromatin depends on the prefoldin-like Bud27 and determines the nucleosome positioning and polyadenylation sites usage in Saccharomyces cerevisiae

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Genome-wide binding of Rpb1 (the largest subunit of the RNA polymerase II) to the chromatin state in bud27∆ and wild-type mutant strains (ChIP-seq)

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Comprehensive transcriptome analysis regarding CDR1AS expression

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Gene expression comparison between yeast histone H2B WT and H2B R95A mutant without and with rapamycin treatment.

Project description:This microarray data is the Affymetrix array of RNA expressed by Wild Type and Mutant strains yeast that is untreated and treated with rapamycin. In yeast, rapamycin inhibits the TORC1 kinase signaling pathway causing rapid alteration in gene expression and ultimately cell cycle arrest in G1 and this study provides a new insight whereby rapamycin signaling via the Torc1 kinase may exploit the pheromone pathway.

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Rapamycin With Grapefruit Juice for Advanced Malignancies

Project description:The purpose of this study is to determine the highest safe dose of rapamycin when given with a fixed amount of grapefruit juice.

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TORC1 signaling pathway inhibition by rapamycin and caffeine affect lifespan, global gene expression and cell proliferation of fission yeast

Project description:Target of rapamycin complex 1 (TORC1) is implicated in growth control and aging from yeast to humans. Fission yeast is emerging as a popular model organism to study TOR signaling, although rapamycin has been thought to not affect cell growth in this organism. Here we analyzed the effects of rapamycin and caffeine, singly and combined, on multiple cellular processes in fission yeast. The two drugs led to diverse and specific phenotypes that depended on TORC1 signaling pathway inhibition, including prolonged chronological lifespan, inhibition of global translation, inhibition of cell growth and division, and reprogramming of global gene expression mimicking nitrogen starvation. Rapamycin and caffeine differentially affected these various TORC1-dependent processes. Combined drug treatment augmented most phenotypes and effectively blocked cell growth. Although rapamycin showed a much more subtle effect on global translation than did caffeine, rapamycin was more effective in prolonging chronological lifespan. Rapamycin prolonged the lifespan of non-growing cells only when applied during the growth phase but not when applied after cells had stopped proliferation. The doses of rapamycin and caffeine strongly correlated with growth inhibition and with lifespan extension. This comprehensive analysis will inform future studies into TORC1 function and cellular aging in fission yeast and beyond.

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