Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [ATAC-seq]

ABSTRACT: Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [ATAC-seq]

PROVIDER: PRJNA544256 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9108760.fastq.gz	Fastqsanger.gz
	SRR9108760_1.fastq.gz	Fastqsanger.gz
	SRR9108760_2.fastq.gz	Fastqsanger.gz
	SRR9108761.fastq.gz	Fastqsanger.gz
	SRR9108761_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection

Project description:Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection

| PRJNA544258 | ENA

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [Bisulfite-Seq]

Project description:Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [Bisulfite-Seq]

| PRJNA544262 | ENA

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [day28 acute vs chronic]

Project description:Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [day28 acute vs chronic]

| PRJNA545698 | ENA

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [day 8 acute vs chronic]

Project description:Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [day 8 acute vs chronic]

| PRJNA545697 | ENA

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [Bisulfite-Seq]

Project description:Chronic CD8 T-cell stimulation in persisting infections or tumors can induce a stable gene expression program, known as T-cell dysfunction or exhaustion, that limits the cell’s effector functions and anti-viral and anti-tumor immunity. Thus far, the underlaying molecular mechanisms that induce and stabilize this phenotype are vaguely understood. We report here that establishing this program requires the thymocyte selection-associated high mobility group-box protein (Tox). Genetic disruption of Tox augments effector function, decreases the expression of PD-1, and significantly enhances immunopathology. These changes are linked to a failure in fixing the dysfunctional phenotype in the critical Tcf1+ progenitor population and to impaired epigenetic programing. Surprisingly, the gains in effector function co-incide with declining numbers of Tcf1+ cells and result ultimately in reduced total numbers of pathogen-specific T-cells. Thus, we establish Tox as a critical factor for the development of T-cell dysfunction and establish a clear link between CD8 T-cell intrinsic suppression of effector function and protection against immune-pathology.

2019-07-03 | GSE131642 | GEO

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [ATAC-seq]

2019-07-03 | GSE131638 | GEO

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [day28 acute vs chronic]

2019-07-03 | GSE132028 | GEO

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection [day 8 acute vs chronic]

2019-07-03 | GSE132027 | GEO

Tox reinforces the phenotype and longevity of dysfunctional T cell populations during chronic viral infection [WT vs KO +/- Tim3]

Project description:Tox reinforces the phenotype and longevity of dysfunctional T cell populations during chronic viral infection [WT vs KO +/- Tim3]

| PRJNA545703 | ENA

Tox reinforces the phenotype and longevity of exhausted T-cells in chronic viral infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-07-03 | GSE131643 | GEO