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Myc is required for adaptive beta cell replication in young mice but is not sufficient in one year old mice fed with a high fat

ABSTRACT: Myc is required for adaptive beta cell replication in young mice but is not sufficient in one year old mice fed with a high fat

PROVIDER: PRJNA545355 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9157170_1.fastq.gz	Fastqsanger.gz
	SRR9157170_2.fastq.gz	Fastqsanger.gz
	SRR9157180_1.fastq.gz	Fastqsanger.gz
	SRR9157180_2.fastq.gz	Fastqsanger.gz
	SRR9157161_1.fastq.gz	Fastqsanger.gz

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Myc is required for adaptive beta cell replication in young mice but is not sufficient in one year old mice fed with a high fat

Project description:Purpose: To test the role of Myc in adaptive expansion of beta cells Methods: Islets were isolated from 8 week old or one year old male C57BL6 mice fed a standard or high fat diet. RNAseq and DNA mehtylseq was performed. Results: RNAseq showed that Myc target genes are upregulted in young, but not old mice after a short term high fat diet. DNA methylation analysis shows hypomethylation of cell cycle genes that are Myc targets in islets from young mice fed with a HFD. Importantly, DNA hypomethylation of Myc response elements does not occur in islets from one-year-old mice fed short-term HFD Conclusions: We conclude that Myc is required for metabolic stress-mediated beta cell expansion in young mice, but with aging Myc upregulation in beta cells is not sufficient to induce beta cell replication by, at least partly, an epigenetically-mediated resistance to Myc action.

2020-09-29 | GSE131941 | GEO

Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet.

Project description:Failure to expand pancreatic β-cells in response to metabolic stress leads to excessive workload resulting in β-cell dysfunction, dedifferentiation, death, and development of type 2 diabetes. In this study, we demonstrate that induction of Myc is required for increased pancreatic β-cell replication and expansion during metabolic stress-induced insulin resistance with short-term high-fat diet (HFD) in young mice. β-Cell-specific Myc knockout mice fail to expand adaptively and show impaired glucose tolerance and β-cell dysfunction. Mechanistically, PKCζ, ERK1/2, mTOR, and PP2A are key regulators of the Myc response in this setting. DNA methylation analysis shows hypomethylation of cell cycle genes that are Myc targets in islets from young mice fed with a short-term HFD. Importantly, DNA hypomethylation of Myc response elements does not occur in islets from 1-year-old mice fed with a short-term HFD, impairing both Myc recruitment to cell cycle regulatory genes and β-cell replication. We conclude that Myc is required for metabolic stress-mediated β-cell expansion in young mice, but with aging, Myc upregulation is not sufficient to induce β-cell replication by, at least partially, an epigenetically mediated resistance to Myc action.

| S-EPMC6754239 | biostudies-literature

Quantitative DIA-Based proteomics of three-year-old and two-year-old Eriocheir sinensis

Project description:Comparative analysis of quantitative DIA-Based proteomics between three-year-old and two-year-old Eriocheir sinensis

2024-04-16 | PXD051511 |

Expression data from one-year-old leaves of Populus simonii by high-temperature treatments

Project description:We take one-year-old plants for high-temperature treatments and controls. We used the Affymetrix Poplar GeneChip to decrypt the gene functions and mechanisms in Populus simonii leaves.

2013-10-12 | GSE41557 | GEO

Expression data from one year old leaves of Populus simonii by NaCl treatments

Project description:We take the one year old plant for 100 mMol/L NaCl treatments 24 hours and controls. Use the Affymetrix poplar gene chip to decrypt the gene functions and mechanisms in Populus simonii leaves. We used microarrays to detail the global programme of gene expression during NaCl treatments.

2014-11-27 | GSE42530 | GEO

Lausannevirus one year microevolution

Project description:Lausannevirus one year genome evolution in allopatric versus sympatric conditions

| PRJEB20258 | ENA

One Year RDX Exposure, Brain Tissue Investigation

Project description:We investigated ecotoxicological effects and toxicogenomic responses in fathead minnows (Pimephales promelas) exposed to an environmentally-relevant concentration (0.83 mg/L) of the munitions compound cyclotrimethylenetrinitramine (RDX) in one year and multi-generational assays. In the one year assay, RDX effects were discerned by comparing breeding groups reared in control or RDX-exposure conditions for one year. RDX had no detectable effect on gonad-somatic index, or condition factor in females assayed at 1 day and at 1, 3, 6, 9, and 12 months, however the liver-somatic index was significantly increased versus controls only at the 12 month time point. RDX had no effect on live-prey capture rates at all time points assayed and no significant impacts on egg production, fertilization or hatch success in the 1-year exposure trial. Genomic analyses indicated that RDX exposure caused limited differential expression of transcripts within time points and no functional conservation of effects indicative of RDX exposure among time points for either brain or liver tissues in the one year exposure. In the multi-generational assay, the effects of acute (96h) exposure to RDX were compared in fish reared to the F2 generation in either control or RDX-exposure conditions. The RDX-reared fish were not observed to have appreciably enhanced RDX tolerance versus the control-reared fish. However, significant differences in gene expression were observed among the control and RDX-reared fish related to neuro-excitatory glutamate metabolism, sensory signaling and processes in neurological development. In total, our results indicate that exposure to an RDX concentration approximating maximum levels observed in the field (0.83 mg/L) caused limited impacts in fathead minnows in a one year exposure, however caused altered expression in genes involved in neural function in a multi-generational exposure.

2010-07-30 | GSE21101 | GEO

One Year RDX Exposure, Liver Tissue Investigation

2010-07-30 | GSE21100 | GEO

Expression data from one-year-old leaves of Populus simonii treated with short-term water deficit

Project description:We take one-year-old plants for short-term water deficit treatments and controls. We use the Affymetrix Poplar GeneChip to decrypt the gene functions and mechanisms in Populus simonii leaves and detail the global program of gene expression during water deficit treatments.

2012-04-27 | GSE37608 | GEO

Expression data from one year old leaves of Populus simonii by chilling stress (4°C, 10h).

Project description:We take the one year old plant for chilling stress (4°C, 10h) and controls.Use the Affymetrix poplar gene chip to decrypt the gene functions and mechanisms in Populus simonii leaves. We used microarrays to detail the global programme of gene expression during chilling stress (4°C, 10h).

2014-05-16 | GSE43872 | GEO

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