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Comparison of wild-type and Kdm7a mutan embryos

ABSTRACT: Comparison of wild-type and Kdm7a mutan embryos

PROVIDER: PRJNA550265 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9586750_1.fastq.gz	Fastqsanger.gz
	SRR9586750_2.fastq.gz	Fastqsanger.gz
	SRR9586760_1.fastq.gz	Fastqsanger.gz
	SRR9586760_2.fastq.gz	Fastqsanger.gz
	SRR9586751_1.fastq.gz	Fastqsanger.gz

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Comparison of gene expression profiles between wild-type and Kdm7a mutan embryos

Project description:Comparison of gene expression profiles between wild-type and Kdm7a mutan embryos

| PRJNA550267 | ENA

Comparison of gene expression profiles between wild-type and Kdm7a mutan embryos

Project description:Temporal and spatial colinear expression of Hox genes determines the specification of positional identities of the embryo. Post-translational modifications of histones contribute to transcriptional regulation, and are required for proper control of biological processes, including differentiation and development. Lysine demethylase 7A (Kdm7a) demethylates lysine 9 di-methylation of histone H3 (H3K9me2) and participates in transcriptional activation of developmental genes. However, the role of Kdm7a during mouse embryonic development remains to be elucidated. Here, we show that Kdm7a-/- mice exhibit anterior homeotic transformation of the axial skeleton (i.e. an increase in the number of presacral elements). Importantly, posterior Hox genes (caudally from Hox9) are specifically down-regulated in Kdm7a-/- embryos, which correlate with increased levels of H3K9me2. Taken together, these data suggest that Kdm7a is able to control transcription of posterior Hox genes, likely through its demethylating activity, and thereby regulating anterior-posterior development in mice.

2019-12-23 | GSE133187 | GEO

Comparison of genome-wide distribution of histone modifications (H3K4me3, H3K9me2, H3K27me2, and H3K27me3) between wild-type and Kdm7a mutant embryos

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Comparison of genome-wide distribution of histone modifications (H3K4me3, H3K9me2, H3K27me2, and H3K27me3) between wild-type and Kdm7a mutant embryos

Project description:Comparison of genome-wide distribution of histone modifications (H3K4me3, H3K9me2, H3K27me2, and H3K27me3) between wild-type and Kdm7a mutant embryos

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Comparison of wild-type and Kdm7a mutan embryos

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-23 | GSE133189 | GEO

zebrafish embryos proteome for slbp2 KO F3 and wild type

Project description:zebrafish embryos proteome for slbp2 KO F3 and wild type at 2.5hpf and 3.5hpf, three replicates for every sample. There are 12 samples in total. Then we analyse the different expressed genes and hope to find out clue which result in serious phenotype of slbp2 KO F3.

2018-11-27 | PXD008614 | Pride

Illumina Microarray of MRC5 cell with or without KDM7A-DT overexpression

Project description:KDM7A Divergent Transcript (KDM7A-DT) is a stress-induced lncRNAs. In our previous studies, KDM7A-DT showed the most robust cellular phenotype alteration and a significant TP53-dependency upon oxidative and oncogenic stress induction. To investigate the functional roles of KDM7A-DT, we first performed overexpression experiments using fibroblasts. We found that MRC5 cells overexpressing KDM7A-DT escaped cell cycle proliferation and long-term survival ability and were associated with a distinct stress-related morphology (enlarged and flattened cells) compared to cells expressing just the vehicle control. To examine the effects of KDM7A-DT overexpression on the transcriptome, we performed a differential expression gene (DEG) analysis comparing a group of four independent biological replicates of MRC5 overexpressing KDM7A-DT to a group of samples from control cells.

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Project description:To study the function of zebrafish Ybx1 during early embryogenesis, we generated maternal ybx1 (Mybx1) mutant using CRISPR/Cas9 and report the transcriptome-wide changes in comparison to wild-type (WT) embryos. Our analysis reveals a dramatic loss of maternal mRNA decay and zygotic genome activation in Mybx1 embryos during maternal-to-zygotic transition.

2018-09-01 | GSE108924 | GEO

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Project description:Transcriptional profiling of drosophila embryos (0-14h collection) comparing embryos double heterozygous for Engrailed and GooseberryNeuro with control wild type embryos

2014-01-01 | GSE46628 | GEO

Binding in wild type embryos: SoxN.

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