Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Escherichia coli strain:MSHS 472 | isolate:Healthy adult with cystitis

ABSTRACT: Escherichia coli strain:MSHS 472 | isolate:Healthy adult with cystitis Genome sequencing

PROVIDER: PRJNA551565 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Escherichia coli strain:MSHS 133 | isolate:Healthy adult with cystitis

Project description:Escherichia coli strain:MSHS 133 | isolate:Healthy adult with cystitis Genome sequencing

| PRJNA551566 | ENA

Adult zymosan re-exposure exacerbates the molecular alterations in the brainstem rostral ventromedial medulla of rats with early life zymosan-induced cystitis.

Project description:Recent evidence suggests that the descending modulatory pathways from the brainstem rostral ventromedial medulla (RVM) are important for bladder inflammatory pain. This study aimed to identify the long-term molecular changes in RVM neurons due to early life cystitis during neuronal development and the effect of reexposure later in adulthood. RVM tissues from two treatment protocols were used: (1) neonatal zymosan exposures with acute adult rechallenge (RC) and (2) only neonatal zymosan exposures (NRC). RNAseq analysis showed upregulation of several genes associated with synaptic plasticity (Grin1, Grip2, Notch1, Arc, and Scn2b) in the cystitis groups compared to controls in both protocols. The RC protocol exhibited a stronger treatment effect with significantly higher fold differences between the groups compared to the NRC protocol (p<0.001, fold differences RC vs NRC). In microarrays, miR-34a-5p showed cystitis-induced downregulation in both protocols. Bioinformatics analysis identified multiple 3’UTRs complementary binding sites for miR-34a-5p on Grin2b, Notch1, Grip2, Scn2b, and Arc genes. The enhanced response in the RC protocol indicates a possible priming effect of early life cystitis on rechallenge in adulthood. These long-term molecular alterations may play a critical role in the development of chronic bladder pain conditions as seen in patients with Interstitial Cystitis/Bladder pain syndrome

2025-01-22 | GSE271334 | GEO

Agrobacterium tumefaciens strain:SEMIA 472 | isolate:SEMIA 472

Project description:Rhizobium radiobacter SEMIA 472 genome sequencing

| PRJNA581073 | ENA

Thlaspi arvense cultivar:2020-M2-472

Project description:Thlaspi arvense 2020-M2-472 Resequencing

| PRJNA1239806 | ENA

Panicum virgatum cultivar:AP13xWBC3xDAC6xVS16 - 472

Project description:Panicum virgatum AP13xWBC3xDAC6xVS16 - 472 - Mapping Population genome sequencing

| PRJNA368606 | ENA

MicroRNAs dysregulation in experimental interstitial cystitis

Project description:We compared the chnages in urinary bladder and iliac lymph nodes microRNAs in the control and experimental autoimmune cystitis in mice. A set of urinary bladder microRNAs (miRNAs) shows profound upregulation or downregulation in the expression profiles of the experimental IC as compared to control.

2021-06-12 | GSE177066 | GEO

interstitial cystitis

Project description:The Characteristic of Urinary Microbiota in Interstitial Cystitis by High Throughput Sequencing

| PRJNA725997 | ENA

Urinary extracellular vesicle microRNA profiling for detection in patients with interstitial cystitis

Project description:Urinay miRNAs could be a powerful classifier for the detection of patients with interstitial cystitis

2022-02-05 | GSE196156 | GEO

The BRD9/7 Inhibitor TP-472 Blocks Melanoma Tumor Growth by Suppressing ECM-Mediated Oncogenic Signaling and Inducing Apoptosis

Project description:Melanoma accounts for the majority of all skin cancer-related deaths and only 1/3rd of melanoma patients with distal metastasis survive beyond five years. However, current therapies including BRAF/MEK targeted therapies or immunotherapies only benefit a subset of melanoma patients due to the emergence of intrinsic or extrinsic resistance mechanisms. Effective treatment of melanoma will thus require new and more effective therapeutic agents. Towards the goal of identifying new therapeutic agents, we conducted an unbiased, druggable epigenetic drug screen using a library of 32 epigenetic inhibitors obtained from the Structural Genome Consortium that targets proteins encoding for epigenetic regulators. This chemical genetic screening identified TP-472, which targets bromodomain-7/9, as the strongest inhibitor of melanoma growth in both short- and long-term survival assays and in mouse models of melanoma tumor growth. Mechanistically, using a transcriptome-wide mRNA sequencing profile we identified TP-472 treatment downregulates genes encoding various extracellular matrix (ECM) proteins, including integrins, collagens, and fibronectins. Reactome-based functional pathway analyses revealed that many of the ECM proteins are involved in extracellular matrix interactions required for cancer cell growth and proliferation. TP-472 treatment also upregulated several pro-apoptotic genes that can inhibit melanoma growth. Collectively, our results identify BRD7/9 inhibitor TP-472 as a potentially useful therapeutic agent for melanoma therapy.

2021-12-23 | GSE179079 | GEO

Cercodemas anceps isolate:A healthy adult individual

Project description:Cercodemas anceps isolate:A healthy adult individual Genome sequencing

| PRJNA1289352 | ENA