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LncRNA-ENST00000501520 promotes the proliferation of malignant-transformed BEAS-2B cells induced with coal tar pitch mediated by target genes

ABSTRACT: LncRNA-ENST00000501520 promotes the proliferation of malignant-transformed BEAS-2B cells induced with coal tar pitch mediated by target genes

PROVIDER: PRJNA553684 | ENA |

REPOSITORIES: ENA

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LncRNA-ENST00000501520 promotes the proliferation of malignant-transformed BEAS-2B cells induced with coal tar pitch mediated by target genes

Project description:Coal tar pitch (CTP) is a byproduct of cooking process which is used in making coatings, corrosion protection materials, and electrode. and it has been verified that Coal tar pitch extract (CTPE) constitutes polycyclic aromatic hydrocarbons (PAHs) (87.91%) and monocyclic aromatic hydrocarbons, heterocyclic compounds and alkenes (the remaining total is 12.09%) using gas chromatography/mass spectrometry (GC/MS). In this study, we determine the lncRNA expression profile in CTPE group and control group. The key lncRNAs were screen out by using microarray analysis in defferent group.

2022-07-08 | GSE134069 | GEO

high-throughput sequencing of circRNAs in T-BEAS-2B cells and C-BEAS-2B cells

Project description:We report the differential expression of circRNAs between T-BEAS-2B cells (cadmium-transformed BEAS-2B cells) and C-BEAS-2B cells (passage-matched control BEAS-2B cells) by high-throughput sequencing. T-BEAS-2B cells are BEAS-2B cells transformed by cadmium at 2.0 μM for twenty weeks, and C-BEAS-2B cells are their passage-matched control. RNAs were sequenced on Illumina HiSeq Xten platform in triplicates, and expressions of circRNAs were calculated by TPM (transcripts per kilobase of exon model per million mapped reads). Clean data per sample exceeds 10 GB. We find 235 significantly up-regulated circRNAs and 271 significantly down-regulated circRNAs in T-BEAS-2B cells relative to C-BEAS-2B cells. Our work provides clues and evidence for exploring the mechanism of circRNAs in cadmium carcinogenesis.

2024-01-26 | GSE165549 | GEO

Comparison of gene expression profiles in chromate transformed BEAS-2B cells

Project description:We established chromate transformed cell lines by chronic exposure of normal human bronchial epithelial BEAS-2B cells to low doses of hexavalent chromium followed by anchorage-independent growth. The gene expression profiles were analyzed in the established cell lines. The gene expression profiles from six chromate transformed cell lines were remarkably similar to each other yet differed significantly from that of either control cell line or normal Beas-2B cells. A total of 409 differentially expressed genes were identified in chromate transformed cells compared to control cells.

2010-09-14 | GSE24025 | GEO

Comparison of gene expression profiles in chromate transformed BEAS-2B cells

2010-09-14 | E-GEOD-24025 | biostudies-arrayexpress

MicroRNA levels in non-transformed and transformed lung cells

Project description:MicroRNA levels in non-transformed BEAS-2B bronchial epithelial cells, two lines of mycoplasma transformed BEAS-2B cells, and A549 lung adenocarcinoma cells were measured. Microarray analyses of 1145 microRNAs in A549 lung adenocarcinoma cells and two other transformed lung cell types relative to BEAS-2B bronchial epithelial cells were performed. 106 miRNAs were down-regulated and 69 miRNAs were up-regulated in all three transformed lines

2014-03-11 | GSE55748 | GEO

Identification of H3K27ac marks influenced by FOXA2 and/or mutant KRAS in BEAS-2B transformed human bronchial epithelial cells

Project description:In order to identify H3K27ac enhancer marks influenced by FOXA2 and/or KRAS.G12V, BEAS-2B cells were infected with lentivirus carrying rat FOXA2 and/or retrovirus carrying human KRAS.G12V. FOXA2 and/or KRAS.G12V-expressing BEAS-2B cells were used for chromatin immunoprecipitation-sequencing (ChIP-seq) to detect genome-wide H3K27ac positive regions.

2025-07-01 | GSE210081 | GEO

Proteome analysis of Beas-2B cells with S. pneumoniae D39

Project description:Proteome analysis of Beas-2B cells with S. pneumoniae D39 after 9 h and 16 h of infection

2023-07-04 | PXD039059 | Pride

HmiOA4.1 microarrays-BEAS-2B cells treatment with NiCl2

Project description:To investigate the effects of nickel on miRNAs expression in BEAS-2B cells.

2018-04-17 | GSE67997 | GEO

BEAS-2B cells: Control versus chemical exposure

Project description:Transcriptonal profiling of BEAS-2B cells: Control versus skin sensitizers; Control versus respiratory sensitizers; Control versus non-sensitizing irritants

2013-12-01 | GSE44729 | GEO

Silica-exposed BEAS-2B epithelial cells

Project description:We used mass spectrometry to profile changes in metabolites, proteins, and phosphorylation in silica-exposed BEAS-2B epithelial cells.

2022-07-28 | PXD035608 |

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