Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Crebl2 regulates cell metabolism in muscle and liver cells (MEFs microarray)

ABSTRACT: Crebl2 regulates cell metabolism in muscle and liver cells (MEFs microarray)

PROVIDER: PRJNA554561 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Crebl2 regulates cell metabolism in muscle and liver cells (MEFs microarray)

Project description:Purpose of this experiment is to investigate whether Crebl2 is required for the transcriptional changes that happen upon rapamycin treatment in TSC2-/- p53-/- MEFs.

2019-12-31 | GSE134244 | GEO

Crebl2 regulates cell metabolism in muscle and liver cells

Project description:Crebl2 regulates cell metabolism in muscle and liver cells

| PRJNA554560 | ENA

Crebl2 regulates cell metabolism in muscle and liver cells (Hepa RNA-seq)

Project description:Crebl2 regulates cell metabolism in muscle and liver cells (Hepa RNA-seq)

| PRJNA554562 | ENA

Crebl2 regulates cell metabolism in muscle and liver cells (C2C12 RNA-seq)

Project description:Crebl2 regulates cell metabolism in muscle and liver cells (C2C12 RNA-seq)

| PRJNA554563 | ENA

The HDAC3 Enzymatic Activity Regulates Skeletal Muscle Fuel Metabolism

Project description:The HDAC3 Enzymatic Activity Regulates Skeletal Muscle Fuel Metabolism

| PRJNA474203 | ENA

Expression data from Microarray experiment in muscle and liver tissues

Project description:Expression data from Microarray experiment in muscle and liver tissues

| PRJNA475145 | ENA

microRNA-1 Regulates Metabolic Flexibility in Skeletal Muscle via Pyruvate Metabolism

Project description:MicroRNA-1 (miR-1) is the most abundant miRNA in adult skeletal muscle. To determine the function of miR-1 in adult skeletal muscle, we generated an inducible, skeletal muscle-specific miR-1 knockout (KO) mouse. Integration of RNA-sequencing (RNA-seq) data from miR-1 KO muscle with Argonaute 2 enhanced crosslinking and immunoprecipitation sequencing (AGO2 eCLIP-seq) from human skeletal muscle identified miR-1 target genes involved with glycolysis and pyruvate metabolism. The loss of miR-1 in skeletal muscle induced cancer-like metabolic reprogramming, as shown by higher pyruvate kinase muscle isozyme M2 (PKM2) protein levels, which promoted glycolysis. Comprehensive bioenergetic and metabolic phenotyping combined with skeletal muscle proteomics and metabolomics further demonstrated that miR-1 KO induced metabolic inflexibility as a result of pyruvate oxidation resistance. While the genetic loss of miR-1 reduced endurance exercise performance in mice and in C. elegans, the physiological down-regulation of miR-1 expression in response to a hypertrophic stimulus in both humans and mice may cause a similar metabolic reprogramming that supports muscle cell growth. Taken together, these data identify a novel post-translational mechanism of adult skeletal muscle metabolism regulation mediated by miR-1.

2024-08-09 | GSE274378 | GEO

Microarray analysis of skeletal muscle in aged mice

Project description:Sarcopenia is the age-induced, progressive loss of skeletal muscle mass and function, which is accompanied by reduced muscle performance. Individuals with sarcopenia often become bedridden or dependent on a wheelchair, leading to decreased quality of life. In this study, to better understand changes in skeletal muscle during sarcopenia, we performed a microarray analysis of skeletal muscle in young (13-week-old) and aged (26-month-old) mice. The microarray data shows that expression of the enzymes related to glucose and polyamine metabolism were decreased in aged mice compared with young mice.

2019-07-28 | GSE125815 | GEO

Microarray analysis of atrophied skeletal muscle models

Project description:Microarray analysis of atrophied skeletal muscle models

| PRJNA381364 | ENA

Microarray analysis of gene expression in ATM-deficient MEFs

Project description:The expression of interferon-related genes was more enhanced in irradiated ATM-deficient mouse embryonic fibroblasts (MEFs) than in irradiated ATM wild-type MEFs.

2012-06-20 | GSE23116 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data