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Circular RNA Expression Profiles in the Plasma from Patients with Heart Failure

ABSTRACT: Circular RNA Expression Profiles in the Plasma from Patients with Heart Failure

PROVIDER: PRJNA555656 | ENA |

REPOSITORIES: ENA

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Circular RNA Expression Profiling in Cardiac Tissue from Heart Failure Patients and Healthy Controls

Project description:Non-coding RNAs (ncRNAs) play critical regulatory roles in cardiovascular pathophysiology, with emerging therapeutic potential for cardiovascular diseases (CVDs). Circular RNAs (circRNAs), a recently characterized subclass of ncRNAs, have garnered significant interest due to their unique covalently closed-loop structures, which confer exceptional stability compared to linear RNAs. These molecules are generated through back-splicing, a non-canonical processing event of pre-mRNA transcripts. CircRNAs exhibit tissue-specific expression patterns, with notable enrichment in cardiac tissue, and demonstrate high evolutionary conservation—properties that underscore their translational relevance. Their functional versatility includes roles as microRNA sponges, protein interactors, and modulators of gene expression, positioning them as promising diagnostic biomarkers and therapeutic targets for cardiovascular conditions, particularly heart failure (HF). This study provides a comparative analysis of circular RNA (circRNA) expression patterns in left ventricular myocardial tissue from patients with heart failure (HF) and healthy controls, revealing differentially expressed circRNAs with potential therapeutic implications. Furthermore, we investigate novel circRNAs that may represent promising candidates for targeted interventions in heart failure.

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Circular RNA Expression Profiles in the Plasma from Patients with Heart Failure

Project description:To identify the circRNA expression profiles in HF patients’ plasma and to evaluate the potential application of circRNAs for HF diagnosis, circRNA microarrays were performed on plasma samples obtained from HF patients and healthy controls. The RNAs of the plasma from the HF and control groups were extracted for microarray analysis. The purified RNAs were hybridized to a microarray (Agilent human circRNA Array V2.0) containing 170,340 human circRNA probes. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the results.

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Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients

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Circular RNA Expression Profiling in Cardiac Tissue from Heart Failure Patients and Healthy Controls

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INO80 and heart failure.

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Project description:Heart Failure Network: EntrestoTM In Advanced Heart Failure (HFN-LIFE-BioLINCC)

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