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Transcriptomic analysis of Tregs from RelB-dDC mice

ABSTRACT: Transcriptomic analysis of Tregs from RelB-dDC mice

PROVIDER: PRJNA556427 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9824470.fastq.gz	Fastqsanger.gz
	SRR9824480.fastq.gz	Fastqsanger.gz
	SRR9824471.fastq.gz	Fastqsanger.gz
	SRR9824481.fastq.gz	Fastqsanger.gz
	SRR9824472.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis of Tregs from RelB-dDC mice

Project description:We report here the effect of RelB ablation in CD11c+ cells on the Treg compartment accross various organs.This mice have been backcrossed to a Foxp3 reporter mouse line to enable cell sorting of Tregs with a high purity. Interestingly, RelB ablation in DCs leads to a substantial accumulation of Tregs and these Tregs show a 'tissue Treg' signature including high expression levels of KLRG1, I1LRL1 and Gata3 when compared to Tregs of littermate control mice.

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