Ontology highlight
ABSTRACT:
PROVIDER: PRJNA559553 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR9949890_1.fastq.gz | Fastqsanger.gz | |||
| SRR9949890_2.fastq.gz | Fastqsanger.gz | |||
| SRR9949900_1.fastq.gz | Fastqsanger.gz | |||
| SRR9949900_2.fastq.gz | Fastqsanger.gz | |||
| SRR9949910_1.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 5 of 120 |
Similar Datasets
Project description:Chandeleur Island 2017 -2018 Amplicon Study Raw sequence reads
| PRJNA514746 | ENA
Project description:Chandeleur Island 2016 Amplicon Study Raw sequence reads
| PRJNA433990 | ENA
Project description:Genomic changes associated with resistance to the pyrethroid insecticide deltamethrin were investigated between six mosquito lines all originating from La Reunion Island. Two of these 6 lines, Sel and NS, derived from the same composite population made by pooling six distinct field populations from La Reunion Island: in the lab, the Sel line was subjected to deltamethrin selection for five successive generations at the adult stage while the NS line was maintained without selection. Three lines correspond to field populations collected in 2018-2029 in three distinct localities (SL: Saint-Louis, SP: Saint Pierre, SS: Sainte-Suzanne. Finally, the susceptible line SRun originating collected in the early 2000s from La Réunion island and maintained in the laboratory since then was also used as a reference.
2026-06-26 | E-MTAB-15456 | biostudies-arrayexpress
Project description:Plasma samples from 35 Malian subjects were used for the proteomic profiling. Samples were collected from 12 individuals aged 7-15 years old, 6 males and 6 females at 4 time points: October 2017 (10 samples), March 2018 (10 samples), May 2018 (19 samples), and 6 samples from malaria cases in August 2018.
2025-05-06 | PXD043980 | Pride
Project description:Fusarium oxysporum is an worldwide economically important plant fungi pathogen that can cause vascular wilt disease on a wide variety of hosts (Williamson et al., 2007). In recent years, extensive research has been conducted to interpret transcriptional regulation of virulence genes in FO. (Weiberg et al., 2013;Brandhoff et al., 2017;Wang et al., 2017;Wang et al., 2018;Porquier et al., 2019). However, gaps in the protein level studies limited deeper understanding of molecular basis of FO. pathogenesis. In this study, we conducted the first proteome-wide analysis in FO.
2023-07-17 | PXD043830 | Pride
Project description:Lewy body (LB) pathology and loss of dopaminergic neurons are imprints of Parkinson’s disease (PD). LBs are mainly comprised of alpha-Synuclein (Dijkstra et al., 2014). Strolling detection of LBs in brain regions contribute to progressive construct of PD pathology to which molecular mechanisms are not clear (H. Braak & Del Tredici, 2017). Two key facets of LB formation are protein aggregation via misfolding and transmission of misfoldled proteins to various brain regions, eventually causing neuronal death (Goedert, Spillantini, Del Tredici, & Braak, 2013; Pacelli et al., 2015). Misfolding requires alterations in intracellular physiology (Carbone, Costa, Provensi, Mannaioni, & Masi, 2017; Funes et al., 2014; Guzman et al., 2018; Pacelli et al., 2015) and detection of misfolded proteins in exosomes confirms exosomatic transmission (Ngolab et al., 2017). High levels of neurotropic-factors (Brockmann et al., 2017) and changes in bioenergetics are found in PD patients, these can bring physiological alterations (Smith et al., 2018). En masse, these evidences and hipocampal association with synucleopathies (Flores-Cuadrado, Ubeda-Bañon, Saiz-Sanchez, de la Rosa-Prieto, & Martinez-Marcos, 2016) allowed us to probe other volunerable PD proteins in cell-lysate and exosomal proteomes of bFGF treated hippocampal neurons. Using WPCNA we developed co-expression modules and spotted many PD related proteins; which can act as precursors during diseased or onset stage.
2020-07-21 | PXD015969 | Pride
Project description:In recent years, several small molecule cytotoxic drugs have been identified as potential inhibitors of ribosome biogenesis (Drygin et al., 2011; Peltonen et al., 2014a; Peltonen et al., 2014b). CX-5461 is one such drug that has also demonstrated anticancer potential for a wide range of malignancies (Bywater et al., 2012; Cornelison et al., 2017; Devlin et al., 2015; Drygin et al., 2011; Hald et al., 2019; Hein et al., 2017; Ismael et al., 2019; Lawrence et al., 2018; Lee et al., 2017; Negi and Brown, 2015; Taylor et al., 2019; Xu et al., 2017; Yan et al., 2017) (Haddach et al., 2012), and is presently under phase I trials for the treatment of both hematological cancers and solid tumours (Group, 2016; Khot et al., 2019). CX-5461 was initially characterized as an inhibitor of RNA Polymerase I (RPI/PolR1/PolI) that is responsible for the synthesis of the major ribosomal RNAs and the initial step in ribosome biogenesis (Drygin et al., 2011). Since RPI and its corresponding core transcription factors are dedicated to this task alone, they present ideal molecular targets by which to modulate ribosome biogenesis. However, the specificity of CX-5461 has been questioned and it has been suggested that this drug may also act by stabilizing DNA G-quadruplexes or by “poisoning” topoisomerase II (Topo II). Thus, the primary target of this drug and its mode of action are still in doubt. Here we used Deconvolution-ChIP-Seq in NIH3T3 and HEK293T cells treated for different times with CX-5461. The data show that the primary target of CX5461 is the initiation of ribosomal RNA gene (rDNA) transcription. CX-5461 blocks transcription initiation in vitro and in vivo by arresting RNA polymerase I (RPI/Pol1) within the preinitiation complex. In contrast to previous suggestions, CX-5461 does not effect recruitment of the TBP-TAF complex SL1 to the rDNA promoter, the recruitment of the initiation competent RPI-Rrn3 complex or ongoing transcription elongation, arguing against a role for G-quadruplex stabilization or topoisomerase II poisoning. Inhibition of transcription by CX-5461 is not reversible, the RPI-Rrn3 complex remains arrested in the preinitiation complex even after drug removal. This leads to nucleolar stress, extensive DNA damage and cell senescence. Our data show that the cytotoxicity of CX-5461 is the downstream result of the highly specific inhibition of rDNA transcription. The observation that this inhibition is irreversible will be important for the future design of chemotherapeutic strategies and the avoidance of drug resistance.
2021-04-07 | E-MTAB-9242 | biostudies-arrayexpress
Project description:Gene expression changes were investigated between six mosquito lines originating from La Reunion Island and correlated with their differential deltamethrin resistance levels. Two of these 6 lines derived from a composite population made by pooling six distinct field populations from La Reunion Island: the Sel line was subjected to deltamethrin selection for five successive generations at the adult stage while the NS line was maintained without selection. Three field populations collected in 2018-2029 in three distinct localities (SL: Saint-Louis, SP: Saint Pierre, SS: Sainte-Suzanne) were also used. Finally, the susceptible line SRun originating collected in the early 2000s from La Réunion island and maintained in the laboratory since then was also used as a reference. For each line, four replicate transcriptomes were generated from 5-days old non-blood fed adult females.
2026-06-25 | E-MTAB-15418 | biostudies-arrayexpress
Project description:Samples from benthic phototrophic microbial mats of Middle Island Sinkhole, Lake Huron, MI, USA. Peptides labeled in vitro for quantitative analysis by diDO-IPTL (Waldbauer et al. 2017 Anal. Chem.).
2022-01-20 | MSV000088706 | MassIVE