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Transcriptional profiling of p53 mutants in KP LUAD cells

ABSTRACT: Transcriptional profiling of p53 mutants in KP LUAD cells

PROVIDER: PRJNA561864 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10033900.fastq.gz	Fastqsanger.gz
	SRR10033901.fastq.gz	Fastqsanger.gz
	SRR10033902.fastq.gz	Fastqsanger.gz
	SRR10033903.fastq.gz	Fastqsanger.gz
	SRR10033904.fastq.gz	Fastqsanger.gz

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Transcriptional profiling of p53 mutants in KP LUAD cells

Project description:Transcriptional profiling of KP LUAD cells expressing a panel of p53 mutant cDNAs.

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RNAseq analysis for transcriptomes of ATO treated U937 cell lines expressing 10 type 1 p53 mutants, type-3 p53-R273H, p53 null, or p53 wild-type

Project description:To globally evaluate to what extend type-1 p53 mutant transcription activity can be restored by arsenic trioxide (ATO) (compared to wild-type p53), p53-null U937 cells introduced with 10 frequent type-1 p53, type-3 p53-R273H (negative control), empty vector or wild-type p53 were treated with or without 1 μg/mL ATO. mRNA was isolated and then subject to deep sequencing, using Illumina HiSeq. The sequence reads that passed quality filters were analyzed using Cutadapt. Results and conclusions: The type-1 p53 mutants are the major cellular targets of ATO in the current cell contexts. The expression profiles of well-established p53 targets in cells expressing wild-type p53 highly correlated with the ones in cells expressing ATO-rescued type-1 mutants, but not those in cells expressing ATO-treated R273H. In cells harboring type-1 mutants, the median expression levels of these targets were elevated by ATO to extents comparable to wild-type p53.

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Gene expression analysis of three tumor organoids (GAN-WT, GAN-p53 and GAN-KP) derived from gastric tumor in K19-Wnt1/C2mE (GAN) mouse.

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