Project description:In order to comprehensively identify genes directly regulated by AP4, a genome-wide chromatin-immunoprecipitation analysis (ChIP) followed by next generation sequencing (ChIP-seq) was performed after activation of a conditional AP4 allele in DLD-1 cells. One DLD-1 Sample was sequenced.

2013-05-31 | E-GEOD-46935 | biostudies-arrayexpress

RNA-seq of colorectal cancer cell line HCT116 and DLD-1 cells treated with PRIMA-1met or oxaliplatin or combination therapy

Project description:RNA-seq of colorectal cancer cell line HCT116 and DLD-1 cells treated with PRIMA-1met or oxaliplatin or combination therapy

2025-01-15 | GSE254323 | GEO

Examination of HMGA2 binding genes in human HMGA2-exogenous overexpressed gastric cancer cells

Project description:HMGA2 significantly increased cell proliferation capacity of gastric cancer in a HMGA2-dependent manner both in vivo and in vitro and we found HMGA2 promoted GC through accelerating S-G2/M phase.To elucidate the underlining mechanism by which HMGA2 induced the change of phenotype in GC cells, we performed ChIP-seq analysis of HMGA2-OE MKN-45 cells with anti-HMGA2 antibody.

2021-08-18 | GSE174442 | GEO

Transcriptome of DLD-1 co-cultured with or without extracellular vesicels derived from Fusobacterium nucleatum

Project description:To explore the impact of FnEV on transcriptome of colorectal cancer cell line DLD-1

2024-05-01 | GSE241656 | GEO

ChIP-seq of AP4 binding in human colorectal cancer cells DLD-1.

2013-05-31 | GSE46935 | GEO

Ectopic expression of AP4 in human colorectal cancer cells DLD-1 for different times

Project description:To characterize the transcriptome of the transcription factor AP4 DLD-1 cells were infected with AP4 coding viruses for different periods of time. Adenovirus amplification and purification was performed as previously described (He et al., 1998). The minimal amount of virus needed to reach more than 90% infection efficiency was determined by monitoring GFP signals with fluorescence microscopy. DLD-1 cells were infected in serum-free medium with adenovirus for 3 hours. After removal an equal amount of medium containing 20% FBS was added.

2013-05-31 | GSE46578 | GEO

RNA-seq profiling of ADAM10 inhibition in DLD-1 and SW620 colorectal cancer cell lines

Project description:This study examines the transcriptomic effects of ADAM10 inhibition in two human colorectal cancer cell lines, DLD-1 and SW620. Cells were treated with vehicle control or the conformation-specific ADAM10 monoclonal antibody 1H5 for 48 hours, followed by extraction of total RNA and paired-end RNA sequencing. The dataset enables comparative analysis of ADAM10-regulated pathways across different CRC genetic backgrounds, including alterations in Notch and EGFR signaling, metabolic gene programs, and other pathways associated with tumor progression.

2026-01-19 | GSE311253 | GEO

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