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Body fluid from the parasitic worm Ascaris suum inhibits broad-acting pro-inflammatory programs in dendritic cells

ABSTRACT: Body fluid from the parasitic worm Ascaris suum inhibits broad-acting pro-inflammatory programs in dendritic cells

PROVIDER: PRJNA564834 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10096568_1.fastq.gz	Fastqsanger.gz
	SRR10096568_2.fastq.gz	Fastqsanger.gz
	SRR10096569_1.fastq.gz	Fastqsanger.gz
	SRR10096569_2.fastq.gz	Fastqsanger.gz
	SRR10096570_1.fastq.gz	Fastqsanger.gz

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Ascaris suum

Project description:Ascaris suum

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Repeat Ascaris challenge reduces worm intensity through gastric cellular reprogramming

Project description:Ascariasis (roundworm) is the most prevalent parasitic nematode infection worldwide, impacting approximately 500 million people predominantly in low- and middle-income countries (LMICs). While people of all ages are infected with Ascaris, infection intensity (defined by worm burden) paradoxically peaks in pre-school and school aged children but then declines with age. The cause of age-dependent Ascaris worm intensity is not well understood but may be dependent on cellular changes in mucosal barrier sites. We have previously found that the gastric mucosa is a critical barrier site for Ascaris infection. Following oral ingestion of Ascaris eggs, larvae use AMCase secreted by gastric chief cells and acid secreted by gastric parietal cells to hatch. Once hatched, larvae translocate across the gastric mucosa to initiate the larval migratory cycle. However, inducing mucosal injury with administration of Tamoxifen induces mucosa cellular changes that impairs Ascaris hatching and reduces larval translocation across the gastric mucosa. In this study we established a repeated Ascaris suum challenge mouse model and evaluated if repeated Ascaris challenge also lead to cellular changes in the gastric mucosal barrier. We found that repeated Ascaris challenge caused cellular changes in the gastric mucosa which reduced worm intensity in the liver independent of the adaptive immune response. Thus, in endemic regions, where individuals experience recurrent infection throughout their lives, gastric cellular changes may be a key mechanism leading to the observed age-dependent Ascaris worm intensity changes from childhood to adulthood.

2025-03-03 | GSE290985 | GEO

Ascaris suum

Project description:Ascaris suum Genome sequencing and assembly

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Ascaris suum

Project description:Ascaris suum Small RNA-Seq data

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Ascaris suum

Project description:Ascaris suum transcriptome (RNA-Seq) data

| PRJNA142041 | ENA

Ascaris suum

Project description:Ascaris suum genome sequencing, assembly and analysis.

| PRJNA286848 | ENA

Ascaris suum

Project description:Ascaris suum North American wild population, Transcriptome Shotgun Assembly

| PRJNA63155 | ENA

Ascaris suum

Project description:Ascaris suum North American wild population, genome sequencing project

| PRJNA62057 | ENA

Ascaris suum strain:wild type

Project description:Ascaris suum circRNA sequencing

| PRJNA750737 | ENA

Ascaris suum transcriptome (RNA-Seq) data

Project description:Eukaryotic cells express several classes of small RNAs that regulate gene expression and ensure genome maintenance. Endogenous siRNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs) mainly control gene and transposon expression in the germline, while microRNAs (miRNAs) generally function in post-transcriptional gene silencing in both somatic and germline cells. To provide an evolutionary and developmental perspective on small RNA pathways in nematodes, we identified and characterized known and novel small RNA classes through gametogenesis and embryo development in the parasitic nematode Ascaris suum and compared them with known small RNAs of Caenorhabditis elegans. piRNAs, Piwi-clade Argonautes, and other proteins associated with the piRNA pathway have been lost in Ascaris. miRNAs are synthesized immediately following fertilization in utero, prior to pronuclear fusion, and before the first cleavage of the zygote. This is the earliest expression of small RNAs ever described at a developmental stage long thought to be transcriptionally quiescent. A comparison of the two classes of Ascaris endo-siRNAs, 22G-RNAs and 26G-RNAs, to those in C. elegans, suggests great diversification and plasticity in the use of small RNA pathways during spermatogenesis in different nematodes. Our data reveal conserved characteristics of nematode small RNAs as well as features unique to Ascaris that illustrate significant flexibility in the use of small RNAs pathways, some of which are likely an adaptation to Ascaris’ life cycle and parasitism.

2011-06-16 | GSE26956 | GEO

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