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Genome-wide analysis of gene expression after knockdown of KDM5B in melanoma cells.

ABSTRACT: Genome-wide analysis of gene expression after knockdown of KDM5B in melanoma cells.

PROVIDER: PRJNA565364 | ENA |

REPOSITORIES: ENA

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Genome-wide analysis of gene expression after knockdown of KDM5B in melanoma cells.

Project description:Analysis of the effects of KDM5B in melanoma cells at gene expression level. Knockdown of KDM5B provides important information about potential target genes of KDM5B.

2022-03-14 | GSE137393 | GEO

Ablation of Histone Demethylase KDM5B in Melanoma Augments Anti-Tumor Immunity through Upregulation of Retroelements [RNA-Seq YUMMER1.7-Kdm5b KO]

Project description:Purpose: Advanced melanoma patients have poor prognosis. Although immune checkpoint blockade has revolutionized treatment for melanoma patients, majority of patients do not respond. The goal of this research is to evaluate whether epigenetic therapy targeting KDM5B could overcome resistance to immunotherapy. Methods:RNA-Seq analysis of KDM5B KO mouse melanoma cell lines compared to control cells to evaluate whether KDM5B depletion induces activation of retroelements, which subsequently activates type I interferon responses. Mouse studies were conducted to evaluate whether anti-tumor immunity induced by KDM5B loss could overcome immunotherapy resistance. Results: We identified that KDM5B depletion derepress retroelement expression, which subsequently activates type I interferon response and enhances anti-tumor immunity. Loss of KDM5B could overcome resistance to anti-PD-1 immunotherapy. Conclusions: Our work characterized ablation of histone demethylase KDM5B in melanoma augments anti-tumor immunity through Upregulation of retroelements.

2021-07-25 | GSE161064 | GEO

Ablation of Histone Demethylase KDM5B in Melanoma Augments Anti-Tumor Immunity through Upregulation of Retroelements [RNA-Seq 1445-Kdm5b KO]

2021-07-25 | GSE161063 | GEO

Ablation of Histone Demethylase KDM5B in Melanoma Augments Anti-Tumor Immunity through Upregulation of Retroelements [ChIP-seq]

2021-07-25 | GSE175542 | GEO

Ablation of Histone Demethylase KDM5B in Melanoma Augments Anti-Tumor Immunity through Upregulation of Retroelements [ChIP-Seq]

2021-07-25 | GSE161062 | GEO

Ablation of Histone Demethylase KDM5B in Melanoma Augments Anti-Tumor Immunity through Upregulation of Retroelements [ATAC-seq]

2021-07-25 | GSE175574 | GEO

YAP1/TAZ knockdown in melanoma

Project description:YAP1/TAZ knockdown in melanoma

| PRJNA1081396 | ENA

Genome-wide analysis of INO80 knockdown

Project description:Genome-wide analysis of INO80 knockdown

| PRJNA931305 | ENA

KDM5B promote tumorigenesis in MCF-7 cells

Project description:RNA-seq analysis was performed to identify key genes and signaling pathways responding to KDM5B knockdown in MCF-7 cells.

2026-02-18 | GSE286884 | GEO

Genome wide analysis of acral melanoma

Project description:This SuperSeries is composed of the following subset Series: GSE28909: Genome wide analysis of acral melanoma (Illumina) GSE28910: Genome wide analysis of acral melanoma (Affymetrix) Refer to individual Series

2011-12-13 | E-GEOD-28913 | biostudies-arrayexpress

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