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Dietary enrichment of BCAA ameliorates cardiac metabolism and function in failing heart

ABSTRACT: Dietary enrichment of BCAA ameliorates cardiac metabolism and function in failing heart

PROVIDER: PRJNA566181 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10139678_1.fastq.gz	Fastqsanger.gz
	SRR10139678_2.fastq.gz	Fastqsanger.gz
	SRR10139679_1.fastq.gz	Fastqsanger.gz
	SRR10139679_2.fastq.gz	Fastqsanger.gz
	SRR10139680_1.fastq.gz	Fastqsanger.gz

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Dietary enrichment of BCAA ameliorates cardiac metabolism and function in failing heart

Project description:Here we show that a specific diet in which dietary protein content has been replaced with a defined-amino acid formula enriched with BCAA, has a remarkable effect in treating heart failure (HF). In particular, we demonstrate that our dietary intervention has a theraputic relevance in the setting of preestablished disease, providing a critical rationale for further development of dietary interventions for HF.

2021-09-01 | GSE137669 | GEO

ChIP-Seq to identify the enrichement of histone acetylation on the promoter of FASN and ACLY in tumors with BCAA dietary interventions.

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BCAA catabolic mutants in prolonged darkness

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Project description:Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone (FSH). Though POI affects many aspects of women’s health, its major causes remain unknown. Many clinical studies have shown that POI patients are generally underweight, indicating a potential correlation between POI and metabolic disorders. To understand the pathogenesis of POI, we performed metabolomics analysis on serum and identified branch chain amino acid (BCAA) insufficiency related metabolic disorders in two independent cohorts from two clinics. A low BCAA diet phenotypically reproduced the metabolic, endocrine, ovarian, and reproductive changes of POI in young C57 B6 mice. A mechanism study revealed that the BCAA insufficiency induced POI is associated with abnormal activation of the ceramide-ROS axis and consequent impairment of ovarian granulosa cell function. Significantly, dietary supplement of BCAA prevented the development of ROS-induced POI in female mice. The results of this pathogenic study will lead to the development of specific therapies for POI.

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Project description:A goal of this study was to identify and investigate previously unrecognized components of the remodeling process in the progression to heart failure by comparing gene expression in ischemic, failing (F) to non-failing (NF) hearts. These results also were compared to the changes observed in a proteomic analysis of F and NF hearts. RNA extracted from the left ventricle was hybridized to Affymetrix arrays to identify gene expression differences in ischemic, end-stage failing versus non-failing hearts. biological replicate: LV_NF_001, LV_NF002, LV_NF004, LV_NF005 biological replicate: LV_F_003, LV_F005, LV_F009, LV_F006

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Dietary intake of a milk sphingolipid-rich MFGM/EV concentrate ameliorates age-related metabolic dysfunction | Plasma | Sprenger et al. 2025

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