Project description:Background: Although the bile acid-mediated microbiome-host interaction is known to shape both the composition and functionality of the gut microbiome, the mechanisms by which bile acid stress influences specific microbial metabolic interactions remain poorly understood. To address this gap, we examine the metabolic interplay between two key gut microbes. Bacteroides thetaiotaomicron, one of the most abundant species, possesses a broad enzymatic repertoire for polysaccharide degradation, while Collinsella aerofaciens is associated with liver-related diseases and plays a role in modifying primary bile acids. Results: In anaerobic coculture, C. aerofaciens mitigated the inhibitory effects of deoxycholic acid (DCA) on B. thetaiotaomicron by absorbing DCA from the medium and partially converting it into glycine-conjugated derivatives. Proteomic analysis showed that DCA broadly disrupted amino acid and vitamin metabolism pathways, particularly in B. thetaiotaomicron. In contrast, coculture led to a general upregulation of these pathways in C. aerofaciens, with a marked activation of vitamin B6 metabolism. Additionally, C. aerofaciens exhibited increased production of citrulline and ornithine in coculture. Conclusions: C. aerofaciens alleviates DCA toxicity on B. thetaiotaomicron through absorption, while promoting amino acid and vitamin metabolism, including the vitamin B6 synthesis pathway, during coculture. These results suggest that microbial interactions can enhance resistance to bile acid stress and may influence gut microbiome resilience, with potential relevance for liver- and bile acid–related disorders.

2026-01-06 | PXD069395 | Pride

Collinsella aerofaciens strain:JCM 10188

Project description:Transcriptional responses of Collinsella aerofaciens JCM 10188 to uric acid and xanthine supplementation in GAM

| PRJDB40455 | ENA

Collinsella aerofaciens TSDC17.1-1.4

Project description:Strain Collinsella aerofaciens TSDC17.1-1.4 (species Collinsella aerofaciens) was isolated from the fecal microbiota of a USA female at time point zero (bacterial isolates were sequenced from this donor on day 0 and 49). The species name was assigned by genome clustering.

| PRJEB3700 | ENA

Collinsella aerofaciens TSDC19.1-1.1

Project description:Strain Collinsella aerofaciens TSDC19.1-1.1 (species Collinsella aerofaciens) was isolated from the fecal microbiota of a USA female at time point zero (bacterial isolates were sequenced from this donor on day 0 and 47). The species name was assigned by genome clustering.

| PRJEB3798 | ENA

Collinsella aerofaciens TSDC17.1-1.1

Project description:Strain Collinsella aerofaciens TSDC17.1-1.1 (species Collinsella aerofaciens) was isolated from the fecal microbiota of a USA female at time point zero (bacterial isolates were sequenced from this donor on day 0 and 49). The species name was assigned by genome clustering.

| PRJEB3697 | ENA

Collinsella aerofaciens TSDC17.1-1.6

Project description:Strain Collinsella aerofaciens TSDC17.1-1.6 (species Collinsella aerofaciens) was isolated from the fecal microbiota of a USA female at time point zero (bacterial isolates were sequenced from this donor on day 0 and 49). The species name was assigned by genome clustering.

| PRJEB3702 | ENA

Collinsella aerofaciens TSDC17.2-2.1

Project description:Strain Collinsella aerofaciens TSDC17.2-2.1 (species Collinsella aerofaciens) was isolated from the fecal microbiota of a USA female at time point zero (bacterial isolates were sequenced from this donor on day 0 and 49). The species name was assigned by genome clustering.

| PRJEB3760 | ENA

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