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Response of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation [Exp1]

ABSTRACT: Response of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation [Exp1]

PROVIDER: PRJNA576498 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10247700.fastq.gz	Fastqsanger.gz
	SRR10247685.fastq.gz	Fastqsanger.gz
	SRR10247686.fastq.gz	Fastqsanger.gz
	SRR10247687.fastq.gz	Fastqsanger.gz
	SRR10247688.fastq.gz	Fastqsanger.gz

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Response of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation [Exp1]

Project description:Immune responses depend on a dynamic balance between the opposing activities of conventional (Tconv) and regulatory (Treg) CD4+ T cells. While receptor-targeted approaches have been developed based on their modulation of Tconv cells, Tconv and Treg cells share many costimulatory receptors. We aim to determine key differential signaling events downstream of costimulation to find opportunities for selective manipulation of Tconv or Treg cells. This data set includes the transcriptomes of expanded human Tconv and Treg cells that were either unstimulated or treated with anti-CD3/CD28 agonistic mAbs for 24 hours.

2020-07-10 | GSE138603 | GEO

Response of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation (Exp1) and to CD28 or TNFR2 costimulation (Exp2)

Project description:Response of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation (Exp1) and to CD28 or TNFR2 costimulation (Exp2)

| PRJNA576496 | ENA

Response of expanded human conventional and regulatory T cells to CD28 or TNFR2 costimulation [Exp2]

Project description:Immune responses depend on a dynamic balance between the opposing activities of conventional (Tconv) and regulatory (Treg) CD4+ T cells. While receptor-targeted approaches have been developed based on their modulation of Tconv cells, Tconv and Treg cells share many costimulatory receptors. We aim to determine key differential signaling events downstream of costimulation to find opportunities for selective manipulation of Tconv or Treg cells. This data set includes the transcriptomes of expanded human Tconv and Treg cells that were treated with anti-CD3, anti-CD3/CD28 or anti-CD3/TNFR2 agonistic mAbs for 24 hours.

2020-07-10 | GSE138604 | GEO

CD3/CD28 signaling, Jurkat E6.1, time course 27 mins

Project description:Fe-IMAC phosphoproteomics using TMT 11plex for quant, of Jurkat T cells stimulated with CD3 and CD28 agonist antibodies for 0, 3, 9, or 27 minutes.

| MSV000092965 | MassIVE

Response of expanded human conventional and regulatory T cells to CD28 or TNFR2 costimulation [Exp2]

Project description:Response of expanded human conventional and regulatory T cells to CD28 or TNFR2 costimulation [Exp2]

| PRJNA576497 | ENA

CD28 region-capture HiC of resting and anti-CD3/CD28-stimuated Jurkat cells

Project description:CD28 region-capture HiC of resting and anti-CD3/CD28-stimuated Jurkat cells

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Genome wide expression profiles (RNAseq) of human CD8+ T cells in resting, activated (CD3+CD28) and PD-1-stimulated cells (CD3+CD28+PD-L1-Fc) at diferent time points

Project description:Background: Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD 1 pathway is widely used for cancer treatment, yet the inhibitory signals transduced by PD-1 in T cells remain elusive. Methods: Expression profiles of human CD8+ T cells in resting, activated (CD3+CD28) and PD-1-stimulated cells (CD3+CD28+PD-L1-Fc) conditions were evaluated by RNA-seq. Bioinformatic analyses were used to identify signaling pathways differentially regulated in PD 1-stimulated cells.

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Response of expanded human conventional and regulatory T cells to CD3/CD28-mediated activation (Exp1) and to CD28 or TNFR2 costimulation (Exp2)

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-10 | GSE138605 | GEO

Gene expression in CD3/CD28 stimulated CD8 vs CD8 with various dosage of Cholesterol treatment

Project description:gene expression in in vitro diffrerentiated CD8 (CD3/CD28 stimulation ) T cells and CD8 T cells treated with Cholesterol

2020-04-14 | GSE112901 | GEO

CD3/CD28 Stimulated versus unstimulated Double-negative T Cells From Sooty Mangabeys

Project description:Transcriptional profiling of Double Negative (CD4-/CD8-) T-cells isolated from SIV infected Sooty Mangebys. DN T-cells were stimulated through the T-Cell receptor using anti CD3/CD28 antibodies for 4 hours and compared to unstimulated DN T-cells.

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