Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gestation and lactation ewe rumen 16S rRNA

ABSTRACT: gestation and lactation ewe rumen 16S rRNA Metagenome

PROVIDER: PRJNA577241 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10289900_1.fastq.gz	Fastqsanger.gz
	SRR10289900_2.fastq.gz	Fastqsanger.gz
	SRR10289901_1.fastq.gz	Fastqsanger.gz
	SRR10289901_2.fastq.gz	Fastqsanger.gz
	SRR10289902_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 124

Similar Datasets

Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_10x]

Project description:The liver undergoes adaptive changes during pregnancy and lactation to meet specific physiological demands, but the precise processes, regulatory mechanisms, and functions remain unclear. Using high-resolution single-cell RNA sequencing (scRNA-seq), we comprehensively analyzed hepatocyte adaptations in mice throughout these periods. Our findings revealed a circular trajectory, termed the “pregnancy clock”, during gestation and non-lactating postpartum phases, reverting to the pre-gestation state after recovery. In contrast, lactation induced a distinct branching pathway, characterized by increased fatty acid synthesis and lipid accumulation. Deletion of Gp130 in the JAK/STAT pathway disrupted gestation transitions, leading to delayed embryonic development, while ACSS2 ablation impaired postpartum lipid metabolism, affecting milk quality and offspring growth. Comparative analysis with sheep demonstrated conserved hepatocyte adaptation pathways despite species-specific genetic regulatory networks. These insights offer potential targets for therapeutic interventions to optimize maternal and fetal health and enhance lactation efficiency, with broad implications for reproductive biology and livestock management.

2025-09-02 | GSE272944 | GEO

Distinct hepatocyte adaptations during gestation and lactation [sheep_SmartSeq3]

2025-09-02 | GSE272943 | GEO

Distinct hepatocyte adaptations during gestation and lactation

Project description:Distinct hepatocyte adaptations during gestation and lactation

| PRJNA1139666 | ENA

Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10]

Project description:Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10]

| PRJNA1251709 | ENA

Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_nuclei]

Project description:Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_nuclei]

| PRJNA1251713 | ENA

Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_10x]

Project description:Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_10x]

| PRJNA1139673 | ENA

Distinct hepatocyte adaptations during gestation and lactation [sheep_SmartSeq3]

Project description:Distinct hepatocyte adaptations during gestation and lactation [sheep_SmartSeq3]

| PRJNA1139674 | ENA

Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_CUT_RUN]

Project description:Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_CUT_RUN]

| PRJNA1251711 | ENA

RNA-Seq data of ruminal epithelial tissue and 16S rRNA sequencing data of rumen digesta in goats infusion of three short-chain fatty acids [16s rRNA-seq]

Project description:Emerging data has highlighted the importance of short-chain fatty acids (SCFAs), particularly butyrate, in regulating ruminal homeostasis in vivo isolated epithelial cells. However, little is known about other SCFAs like acetate or propionate, and the interaction between rumen microbes and epithelial immunity are rarely reported. Here, we firstly combined infusion of three SCFAs, to study their different roles in ruminal development, antioxidant capacity, barrier functions, and immunity, as well as cross-talk with ruminal microbiome (16S rRNA sequencing data of rumen digesta) and derived transcriptome (RNA-Seq) and metabolism using an in vivo goat model.

2022-12-26 | GSE221508 | GEO

Distinct hepatocyte adaptations during gestation and lactation [pregnant_liver_mm10_nuclei]

Project description:Using high-resolution single-cell RNA sequencing, we systematically characterized hepatocyte adaptations in mice across pregnancy and postpartum stages. We discovered a cyclical hepatocyte trajectory (“pregnancy clock”) governing metabolic changes during gestation and postpartum recovery, which reverted to pregestational states in non-lactating mice. Lactation induced a distinct branching trajectory characterized by elevated lipid synthesis and export. Deletion of gp130 disrupted hepatic adaptations during pregnancy, impairing fetal growth, whereas ACSS2 deficiency postpartum disrupted lipid export, affecting milk quality and offspring growth.

2025-09-02 | GSE294860 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data