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RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells

ABSTRACT: RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells

PROVIDER: PRJNA577837 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10291461.fastq.gz	Fastqsanger.gz
	SRR10291462.fastq.gz	Fastqsanger.gz
	SRR10291463.fastq.gz	Fastqsanger.gz
	SRR10291464.fastq.gz	Fastqsanger.gz
	SRR10291465.fastq.gz	Fastqsanger.gz

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RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th17 cells

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RNA sequencing of naïve, Th1 and Th2 polarised live CD4+ T cells from CD4Cre+ and CD4Cre+DOT1LFL/FL mice

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RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells

Project description:The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we determined transcriptional changes in Th1 cells upon deletion of the cofactor NCOR1.

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RNA-sequencing of in vitro differentiated WT and Chi3l1 KO Th1 cell

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RNA-sequencing of in vitro differentiated WT and Chi3l1 KO Th1 cell

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RNA sequencing of naïve, Th1 and Th2 polarised live CD4+ T cells from CD4Cre+ and CD4Cre+DOT1LFL/FL mice

Project description:RNA sequencing of naïve, Th1 and Th2 polarised live CD4+ T cells from CD4Cre+ and CD4Cre+DOT1LFL/FL mice

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Transcriptome Analysis of Follicular Helper T cells, Central Memory Precursors, and Terminal Effector Th1 Cells from Wild Type and Stat3fl/fl Cd4cre mice

Project description:Purpose: To compare the transcriptomes of activated CD4 T effector cell populations in the presence and absence of STAT3 at 8 days post-infection using high-throughput RNA sequencing analysis. Methods: Cell sorting of the populations was done using the markers Ly6c and PSGL-1 CD4 T cell Ly6c and PSGL-1 population mRNA profiles 8 days post-LCMV infection of wild type (WT) and STAT3fl/fl Cd4cre mice were generated by mRNA sequencing using Illumina HiSeq 2000.

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FoxO4 ChIP-Seq profiles of WT differentiated TH1 cells

Project description:This study is to analyze genome-wide occupancy of FoxO4 in WT TH1 cells.

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RNA-seq analysis of WT and NCOR1f/f,Cd4Cre naive CD4+ T cells

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Transcription Factor p73 Regulates Th1 Differentiation

Project description:Inter-individual differences in T helper (Th) cell responses affect susceptibility to infectious, allergic, and autoimmune diseases. To identify factors contributing to these response differences, we analyzed the phenotypic profiles of in vitro-differentiated Th1 cells from 16 inbred mouse strains. Haplotype-based computational genetic analysis indicated that the p53 family protein, p73, affected Th1 differentiation. In cells differentiated under Th1 conditions in vitro, we demonstrated that p73 was a negative regulator of IFNγ production, and this effect required the DNA-binding activity of p73. p73 bound within the gene body or upstream of many genes that affect Th1 differentiation and regulated their expression (e.g., Ifng and Il12rb2). Furthermore, in experimental autoimmune encephalitis, which is a mouse disease model of multiple sclerosis, p73-deficient mice had increased IFNg production and decreased disease severity, whereas in the adoptive transfer model of inflammatory bowel disease, transfer of p73- deficient naïve CD4+ T cells into WT Rag2-/- hosts resulted in increased Th1 responses and enhanced disease severity compared to transfer of WT cells. These studies identify p73 as a regulator of immune responses and indicate that its dysregulation may play a role in susceptibility to autoimmune disease.

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