Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Early-life environmental enrichment generates persistent individualized behavior in mice

ABSTRACT: Early-life environmental enrichment generates persistent individualized behavior in mice

PROVIDER: PRJNA578151 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10302663.fastq.gz	Fastqsanger.gz
	SRR10302664.fastq.gz	Fastqsanger.gz
	SRR10302665.fastq.gz	Fastqsanger.gz
	SRR10302666.fastq.gz	Fastqsanger.gz
	SRR10302667.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 15

Similar Datasets

Early-life environmental enrichment generates persistent individualized behavior in mice

Project description:Analysis of hippocampal DNA methylation changes that were induced by environmental enrichment and maintained for long-term after withdrawal from the enriched environment.

2020-08-26 | GSE139051 | GEO

Early-life environmental enrichment generates persistent individualized behavior in mice.

Project description:Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cages over periods of 3 to 6 months. We show that behavioral individuality that emerged during the first 3 months of environmental enrichment persisted when mice were withdrawn from the enriched environment for 3 additional months. Behavioral trajectories were associated with stable interindividual differences in adult hippocampal neurogenesis and persistent epigenetic effects on neuronal plasticity genes in the hippocampus. Using genome-wide DNA methylation sequencing, we show that one-third of the DNA methylation changes were maintained after withdrawal from the enriched environment. Our results suggest that, even under conditions that control genetic background and shared environment, early-life experiences result in lasting individualized changes in behavior, brain plasticity, and epigenetics.

| S-EPMC7449688 | biostudies-literature

A realistic mixture of Persistent Organic Pollutants affects zebrafish embryogenesis and behavior

Project description:A realistic mixture of Persistent Organic Pollutants affects zebrafish embryogenesis and behavior

| PRJNA858016 | ENA

Repeated cortico-striatal stimulation generates persistent OCD-like behavior.

Project description:Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)-ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated hyperactivation over multiple days generated a progressive increase in grooming, a mouse behavior related to OCD. Increased grooming persisted for 2 weeks after stimulation cessation. The grooming increase was temporally coupled with a progressive increase in light-evoked firing of postsynaptic VMS cells. Both increased grooming and evoked firing were reversed by chronic fluoxetine, a first-line OCD treatment. Brief but repeated episodes of abnormal circuit activity may thus set the stage for the development of persistent psychopathology.

| S-EPMC3954809 | biostudies-literature

RNA-seq alignment to individualized genomes

2014-06-10 | GSE45684 | GEO

RNA-seq alignment to individualized genomes

Project description:The source of most errors in RNA sequencing (RNA-seq) read alignment is in the repetitive structure of the genome and not with the alignment algorithm. Genetic variation away from the reference sequence exacerbates this problem causing reads to be assigned to the wrong location. We developed a method, implemented as the software package Seqnature, to construct the imputed genomes of individuals (individualized genomes) of experimental model organisms including inbred mouse strains and genetically unique outbred animals. Alignment to individualized genomes increases read mapping accuracy and improves transcript abundance estimates. In an application to expression QTL mapping, this approach corrected erroneous linkages and unmasked thousands of hidden associations. Individualized genomes accounting for genetic variation will be useful for human short-read sequencing and other sequencing applications including ChIP-seq. Illumina 100bp single-end liver RNA-seq from 277 male and female Diversity Outbred 26-week old mice raised on standard chow or high fat diet. In addition, Illumina 100bp single-end liver RNA-seq from 128 male 26-week old male mice (20 weeks for NZO strain) from each of the DO founder strains raised on standard chow or high fat diet (8 males per strain by diet group). Each sample was sequenced in 2-4x technical replicates across multiple flowcells. Samples were randomly assigned lanes and multiplexed at 12-24x.

2014-06-10 | E-GEOD-45684 | biostudies-arrayexpress

ncRNA expression-based, individualized outcome prediction for CRC patients

Project description:Individualized outcome prediction classifiers were successfully constructed through expression profiling of ncRNAs in 165 CRC cases.

2016-12-28 | GSE92928 | GEO

Gene expression-based, individualized outcome prediction for autism

Project description:Individualized outcome prediction classifiers were successfully constructed through expression profiling of 91 up-regulated and 67 down-regulated miRNAs in 5 autism spectrum disorder (ASD) cases and 5 controls.

2015-04-17 | GSE67979 | GEO

Gene silenced-based, individualized cancer progression outcome prediction for shATMIN stable transfectants

Project description:Individualized outcome prediction classifiers were successfully constructed through expression profiling in stable transfectants

2019-05-25 | GSE81866 | GEO

Gene expression-based, individualized outcome prediction for RUNX1T1 Knock-down treated ECFCs

Project description:Individualized outcome prediction classifiers were successfully constructed through expression profiling of RUNX1T1 mediated.

2017-08-17 | GSE86594 | GEO