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Rank pathway activation attenuates mammary tumorigenesis by inducing senescence

ABSTRACT: Rank pathway activation attenuates mammary tumorigenesis by inducing senescence

PROVIDER: PRJNA586861 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10380270.fastq.gz	Fastqsanger.gz
	SRR10380271.fastq.gz	Fastqsanger.gz
	SRR10380272.fastq.gz	Fastqsanger.gz
	SRR10380273.fastq.gz	Fastqsanger.gz
	SRR10380274.fastq.gz	Fastqsanger.gz

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Rank pathway activation attenuates mammary tumorigenesis by inducing senescence

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Project description:The purpose of this study was to elucidate the molecular changes of the mammary epithelium induced by luminal cell specific RANK deletion. We have characterized the phenotypic consequences of RANK deletion in the luminal lineage of the mammary epithelium, and uncovered that Rank KO luminal cells have reduced long term renewal following sucessive pregnancies. Lineage tracing analysis has demonstrated that during pregnancy 2, Rank deleted luminal cells are repleace by a wt luminal cell population, derived from the basal epithelium. We therefore decided to perform RNA seq in resting mammary glands from virgin and parous (following pregnancy one) females, cells were FACS sorted based on the traditional markers CD24 and CD49f and in the case of luminal cells GFP (recombined cells). We have isolated luminal cells to identify the molecular pathways involved in reduced long term renewal oberved in the parous context; basal cells were isolated to adress the putative mechanims regulated the bipotency observed during second pregnancy

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Project description:RANK-positive and RANK-negative luminal progenitor cells were isolated by FACS from histologically normal human breast tissue from wild-type human donors. RNA-seq gene expression profiling was used to find differentially expressed genes between the RANK-positive and RANK-negative cell populations.

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Sirt6 attenuates chondrocyte senescence and osteoarthritis progression

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Comparison of WapCre;Rank;Brca1;p53 and WapCre;Brca1;p53 mouse primary mammary tumors

Project description:The transcriptional profile of WapCre;Rank;Brca1;p53 and WapCre;Brca1;p53 mouse primary mammary tumor cells was determined by mRNA sequencing and uncovered differences in their molecular signatures including genes involved in oncogenesis, basic metabolism, RNA metabolism, or the regulation of mammary stem cells.

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