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Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming

ABSTRACT: Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming

PROVIDER: PRJNA589024 | ENA |

REPOSITORIES: ENA

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Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming (RNA-Seq)

Project description:Evolutionarily conserved SCAN domain-containing zinc finger transcription factors (ZSCAN) have been found in both the mouse and human genomes. Of which, Zscan4 is crucial for zygotic genome activation (ZGA) in preimplantation embryos, and induced pluripotent stem cell (iPSC) reprogramming. However, little is known about the mechanism of Zscan4 underlying these processes of cell fate control. Here we show that Zscan4f, a representative of ZSCAN proteins, is able to recruit Tet2 through its SCAN domain. The Zscan4f-Tet2 interaction promotes DNA demethylation and regulates the expression of target genes, particularly those encoding glycolytic enzymes and proteasome subunits. Disruption of the Zscan4f-Tet2 interaction impairs cellular metabolism, proteasome function, and ultimately compromises iPSC generation. These results identify Tet2 as a major cooperator for the function of Zscan4f, and suggest a common mechanism shared by SCAN family transcription factors to recruit TET DNA dioxygenases to regulate diverse cellular processes.

2019-11-13 | GSE140237 | GEO

Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming (ChIP-Seq)

2019-11-13 | GSE140236 | GEO

Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming (ChIP-Seq)

Project description:Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming (ChIP-Seq)

| PRJNA589029 | ENA

Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming (RNA-Seq)

Project description:Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming (RNA-Seq)

| PRJNA589034 | ENA

Tet2 interacts with SCAN domain and regulates Zscan4-associated events during cell reprogramming

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-11-13 | GSE140239 | GEO

OGT, H2B S112GlcNAc, TET2 ChIP-seq results

Project description:TET2 directly interacts with OGT, which is important for the chromatin association of OGT in vivo. Although this specific interaction does not regulate the enzymatic activity of TET2, it facilitates OGT-dependent histone O-GlcNAcylation. Moreover, OGT associates with TET2 at transcription starting sites (TSS). Down-regulation of TET2 reduces the amount of H2B S112 GlcNAc marks in vivo, which are associated with gene transcription regulation. We found that OGT interacts with TET2 tightly. Using ChIP-seq with specific antibodies, we tested the co-localization of TET2 and OGT in genome level.

2012-12-11 | E-GEOD-41720 | biostudies-arrayexpress

ZSCAN4

Project description:Homo sapiens ZSCAN4, zinc finger and SCAN domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23709], is differentially expressed in 36 experiment(s);

| ENSG00000180532 | ExpressionAtlas

ZSCAN4

Project description:Homo sapiens ZSCAN4, zinc finger and SCAN domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23709], is expressed in 18 baseline experiment(s);

| ENSG00000180532 | ExpressionAtlas

ZSCAN4

Project description:Macaca mulatta ZSCAN4, zinc finger and SCAN domain containing 4 [Source:VGNC Symbol;Acc:VGNC:79403], is expressed in 2 baseline experiment(s);

| ENSMMUG00000005335 | ExpressionAtlas

ZSCAN4

Project description:Chlorocebus sabaeus ZSCAN4, zinc finger and SCAN domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23709], is expressed in 1 baseline experiment(s);

| ENSCSAG00000001623 | ExpressionAtlas

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