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Microarray profiling analysis ofcircular RNAs expression in osteosarcoma

ABSTRACT: Microarray profiling analysis ofcircular RNAs expression in osteosarcoma

PROVIDER: PRJNA589051 | ENA |

REPOSITORIES: ENA

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Microarray profiling analysis ofcircular RNAs expression in osteosarcoma

Project description:Strategies targeted vascular endothelial growth factor (VEGF)-dependent osteosarcoma progression are limited although important progress has been made in illustrating the mechanisms. Here we identified circ_001621 as one of the significantly upregulated circular RNAs (circRNAs) by circRNAs microarrays. We found that patients with high circ_001621 expression had a shorter survival time. Moreover, we found several potential sponge micro RNAs (miRNA) of circ_001621 with Circular RNA Interactome database. Among the candidate sponge, we elucidated the association of circ_001621 and miR-578. In addition, we demonstrated that miR-578 targeted circ_001621 directly. Functionally, we set up the experimental system to investigate the effects of circ_001621/miR-578/VEGF interaction in vitro and in vivo. Results indicated circ_001621 promoted osteosarcoma proliferation and migration via attenuating the inhibition of cyclin-dependent kinase 4 (CDK4) and matrix metallopeptidase 9 (MMP9) by miR-578, respectively. Nude mice experiment was further performed to estimate the promotion of metastasis by circ_001621. The present study evaluated the mechanisms underlying circ_001621 enhanced osteosarcoma progression and provided novel therapeutic targets for advanced osteosarcoma. Circular RNAs profiling by array

2020-01-14 | GSE140256 | GEO

Microarray profiling analysis of whole transcriptome expression in osteosarcoma

Project description:Microarray profiling analysis of whole transcriptome expression in osteosarcoma

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Microarray expression profile and functional analysis of circular RNAs in osteosarcoma

Project description:Seven human osteosarcoma cell lines (U2OS, U2OS/MTX300, HOS, MG63, 143B, ZOS, ZOSM) and the human osteoblast hFOB1.19 were included in the study. Microarray based circRNA expression profiles were acquired using the Arraystar Human circRNA Array (8x15K, Arraystar). We identified circRNAs differentially expressed in human osteosarcoma cell lines compared to human osteoblast hFOB1.19 (control).

2017-04-12 | GSE96964 | GEO

Microarray profiling analysis of whole transcriptome expression in osteosarcoma

Project description:Osteosarcoma (OS)is a rare primary malignant bone tumor in adolescents and children with a poor prognosis. Identification of prognostic genes lags far behind the advance of the treatments. We identified differential genes by microarray analysis from paired OS tissues. Hub genes, gene set enrichment analysis, and pathway analysis were performed to gain an insight into the pathway alterations of OS. These results showed CPE could be served as a prognostic factor in osteoblastic OS and should be further investigated as potential therapeutic target. The present study evaluated the whole transcriptome expression of osteosarcoma progression and provided novel therapeutic targets for advanced osteosarcoma.

2023-03-01 | GSE225588 | GEO

Microarray profiling analysis of circular RNAs expression in bladder cancer

Project description:Microarray profiling analysis of circular RNAs expression in bladder cancer

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Microarray profiling analysis of circular RNAs expression in bladder cancer [lncRNA profiling]

Project description:Microarray profiling analysis of circular RNAs expression in bladder cancer [lncRNA profiling]

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Microarray profiling analysis of circular RNAs expression in bladder cancer [miRNA profiling]

Project description:Microarray profiling analysis of circular RNAs expression in bladder cancer [miRNA profiling]

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Microarray profiling analysis of long non-coding RNAs expression in osteoarthritis

Project description:Microarray profiling analysis of long non-coding RNAs expression in osteoarthritis

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Gene function analysis in osteosarcoma based on microarray gene expression profiling.

Project description: Not available

| S-EPMC4565213 | biostudies-literature

Microarray profiling analysis of long non-coding RNAs expression in osteoarthritis

Project description:Osteoarthritis (OA) is the most common motor system disease in aging people, characterized by matrix degradation, chondrocyte death, and osteophyte formation. OA etiology is unclear, but long noncoding RNAs (lncRNAs) that participate in numerous pathological and physiological processes may be key regulators in the onset and development of OA. Because profiling of lncRNAs and their biological function in OA is not understood, we measured lncRNA and mRNA expression profiles using high-throughput microarray to study human knee OA. We identified 2,042 lncRNAs and 2,011 mRNAs that were significantly differentially expressed in OA compared to non-OA tissue (>2.0- or <-2.0-fold change; p<0.5), including 1,137 lncRNAs that were upregulated and 905 lncRNAs that were downregulated. Also, 1,386 mRNA were upregulated and 625 mRNAs were downregulated. Gene Ontology analysis and the Kyoto Encyclopedia of Genes and Genomes was used to study the biological function enrichment of differentially expressed mRNA. Additionally, coding-non-coding gene co-expression (CNC) network construction was performed to explore the relevance of dysregulated lncRNAs and mRNAs. Finally, QPCR was used to validate chip results. In general, this study provides a preliminary database for further exploring lncRNA-related mechnisms in OA. OA cartilage were collected from 19 patients undergoing total knee joint replacement due to severe OA, and normal cartilage were collected from 11 patients (trauma, thromboangiities obliterans, or osteosarcoma, or limb amputation) without history of rheumatoid arthritis or OA

2018-05-11 | GSE113825 | GEO

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