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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

ABSTRACT: Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

PROVIDER: PRJNA594276 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10611200.fastq.gz	Fastqsanger.gz
	SRR10611201.fastq.gz	Fastqsanger.gz
	SRR10611202.fastq.gz	Fastqsanger.gz
	SRR10611203.fastq.gz	Fastqsanger.gz
	SRR10611204.fastq.gz	Fastqsanger.gz

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [RNA-seq]

Project description:Dendritic cell (DC) subsets are critical for immune responses, but their development from progenitors and maturation are often altered during infection, and the mechanisms underlying these changes remain unclear. To address this problem, we investigated the transcriptomes of bone marrow DC progenitors from mice infected with lymphocytic choriomeningitis virus (LCMV).

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq]

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq_IFNARblockade]

Project description:Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [ATAC-seq_IFNARblockade]

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection [RNA-seq]

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Project description:IFN-I suppresses the number of pre-pDCs and pDC development after infection, and the mechanisms underlying these changes remain unclear. To address this problem, we investigated the chromatin landscapes of bone marrow DC progenitors from mice infected with lymphocytic choriomeningitis virus (LCMV) after IFN-I receptor blockade with neutralizing antibodies.

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Gene expression changes in bone marrow dendritic cell progenitors upon acute and chronic LCMV infection

Project description:This SuperSeries is composed of the SubSeries listed below.

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Dendritic cell and monocyte progenitors

Project description:To compare the gene expression profiles of Macrophage & Dendritic cell Progenitors (MDPs), Common Dendritic cell Progenitors (CDPs), committed dendritic cell precursors (pre-DCs), and Ly6Chi monocytes from mouse bone marrow Four samples (MDPs, CDPs, pre-DCs, and monocytes) were collected in triplicate

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Dendritic cell and monocyte progenitors

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Restricted Dendritic Cell and Monocyte Progenitors in Human Cord Blood and Bone Marrow

Project description:In mice, two restricted DC progenitors, macrophage-dendritic progenitor (MDP) and common dendritic cell progenitor (CDP) demonstrate increasing commitment of DC lineage as they sequentially lose granulocyte and monocyte potential respectively. Identifying these progenitors has enabled understanding of the role of DCs and monocytes in immunity and tolerance in mice. In humans, however, restricted monocyte and DC progenitors remain unknown. Progress in studying human DC development has been hampered by lack of an in vitro culture system that recapitulates in vivo DC hematopoiesis. Here we report a culture system that supports development of CD34+ hematopoietic stem cell progenitors into the three major human DC subsets, monocytes, granulocytes, NK and B cells. Using this culture system we defined the pathway for human DC development, and revealed the sequential origin of human DCs from increasingly restricted progenitors: a granulocyte-monocyte-DC progenitor (hGMDP) that develops into a monocyte-DC progenitor (hMDP) that develops into monocytes and a common DC progenitor (hCDP) that is restricted to produce the three major DC subsets. The phenotype of the DC progenitors partially overlaps with granulocyte monocyte progenitors (GMPs). These progenitors reside in human cord blood and bone marrow but not in the blood or lymphoid tissues in the steady state. We performed whole transcriptome expression analysis on monocytes and subsets of dendritic cells i.e. CD1c+ DCs, CD141+ DCs and CD303+ pDCs isolated from blood or differentiated in culture from cord blood CD34+ cells in presence of MS5 stromal cells and Flt3l, GM-CSF and SCF cytokines.

2015-01-22 | E-GEOD-65128 | biostudies-arrayexpress

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