Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tracking epigenetic changes during human leukemogenesis

ABSTRACT: Tracking epigenetic changes during human leukemogenesis

PROVIDER: PRJNA597528 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10764800_1.fastq.gz	Fastqsanger.gz
	SRR10764800_2.fastq.gz	Fastqsanger.gz
	SRR10764900_1.fastq.gz	Fastqsanger.gz
	SRR10764900_2.fastq.gz	Fastqsanger.gz
	SRR10764801_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 390

Similar Datasets

Epigenetic changes in Down syndrome leukemogenesis

Project description:Epigenetic changes in Down syndrome leukemogenesis

| PRJNA197487 | ENA

Tracking epigenetic changes during human leukemogenesis

Project description:We have developed a human model leukemia system where healthy cord blood (CB) cells from single donors are used to generate dozens of human leukemias driven by KMT2A fusions. These models have been used for the study of the stepwise changes in donor CB cells as they undergo leukemic transformation driven by the KMT2A-MLLT3 (KM3) fusion gene. We specifically studied the epigenetic changes that occur in this specific AML subgroup through ChIP-seq of histone modifications and ATAC-seq and DNA methylation through Methyl-Seq.

2020-07-01 | GSE142579 | GEO

Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Project description:Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

| PRJNA488066 | ENA

Epigenetic changes in Down syndrome leukemogenesis

Project description:Acute megakaryoblastic leukemia (AMKL) is more frequently seen in Down syndrome patients, where it is often preceded by a transient myeloproliferative disorder (DS-TMD). The development of DS-TMD and DS-AMKL require not only the presence of the trisomy 21 but also that of GATA1 mutations. However, despite extensive studies into the genetics of DS-AMKL, not much is known about the epigenetic deregulation associated with this disease. In order to understand how epigenetic changes at the DNA methylation level contribute to DS leukemogenesis we performed DNA methylation profiling at different stages of development of this disease and analyzed the dynamics of epigenetic reprogramming. Early genome-wide epigenetic changes can be detected in trisomy 21 fetal liver mononuclear cells, even prior to the development of hematological abnormalities. These early changes are characterized by marked loss of DNA methylation at genes associated with regulation of key developmental processes. This first wave of aberrant DNA hypomethylation is followed by a second wave of epigenetic reprogramming detected in blast cells from DS-TMD and DS-AMKL, characterized by gains of methylation. This second wave of hypermethylation targets a distinct set of genes, preferentially affecting genes involved in hematopoiesis and regulation of cell growth and proliferation. DNA methylation profiles obtained at different stages of the development of Down syndrome AMKL and from CD41+ cells from partial trisomic mice

2013-08-19 | E-GEOD-46167 | biostudies-arrayexpress