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Transcriptome profiling (RNA-seq) analysis of control and NaIO3-treated RPE cells

ABSTRACT: Transcriptome profiling (RNA-seq) analysis of control and NaIO3-treated RPE cells

PROVIDER: PRJNA597602 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10766046_1.fastq.gz	Fastqsanger.gz
	SRR10766046_2.fastq.gz	Fastqsanger.gz
	SRR10766047_1.fastq.gz	Fastqsanger.gz
	SRR10766047_2.fastq.gz	Fastqsanger.gz
	SRR10766048_1.fastq.gz	Fastqsanger.gz

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Transcriptome profiling (RNA-seq) analysis of control and NaIO3-treated RPE cells

Project description:Purpose: The goal of this experiment is to investigate the relative contributions of various types of cell death in NaIO3-treated RPE cells Methods: RPE cell mRNA profiles were generated by deep sequencing, in triplicate, using Illumina HiSeq 4000. Results: According to the differential expressions of mRNA genes, among which 661 genes were upregulated and 637 genes were downregulated with significance after NaIO3 treatment . From the Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, it has been identified that ferroptosis ranked as the top pathway in comparison to other types of cell death (apoptosis, and necroptosis) upon NaIO3 treatment, which was additionally validated by the higher FPKM of main regulators in ferroptosis than that in apoptosis. Additionally, it was found that heme oxygenase-1 (HMOX1, also known as HO-1) as well as SLC7A11 (solute carrier family 7 member 11) mRNA were characterized as the most dramatically upregulated genes upon NaIO3 treatment against ARPE-19 cells Conclusions: Our study represented that ferroptosis serves as a predominant pathogenic factor involved in AMD pathological process.

2019-12-26 | GSE142591 | GEO

Transcriptome profiling (RNA-seq) analysis of NaIO3-induced RPE cells with or witout CaPB treatment

Project description:Purpose: The goal of this experiment is to investigate the role of CaPB in NaIO3-induced RPE cells Methods: RPE cell mRNA profiles were generated by deep sequencing, in triplicate, using Illumina HiSeq 4000. Results: According to the differential expressions of mRNA genes, among which 463 genes were upregulated and 397 genes were downregulated with significance in NaIO3-induced RPE cells after CaPB treatment . From the Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, it has been identified that ferroptosis ranked as the most downregulated pathway upon CaPB treatment. Conclusions: Our study represented that CaPB against NaIO3-treated RPE cell death via ferroptosis inhibition

2020-12-22 | GSE163591 | GEO

m6A Epitranscriptomic Microarray of primary mouse RPE cells treated with TGF-β2

Project description:m6A-mRNA&lncRNA Epitranscriptomic Microarray of primary mouse RPE cells comparing control untreated RPE cells with RPE cells treated with TGF-β2 at a concentration of 10 ng/ml. The goal was to determine the effects of RNA m6a methylation on primary mouse RPE cells undergoing epithelial-mesenchymal transition induced by TGF-β2.

2021-06-26 | GSE178946 | GEO

RFX7, ANKRA2, and p53-regulated transcriptome in RPE-1

Project description:Identification of the RFX7-regulated transcriptome in Nutlin-3a and DMSO control treated RPE-1 cells

2021-06-20 | GSE162161 | GEO

QuantSeq from Nutlin-3a-treated MCF-7, U2OS, and RPE-1 cells

Project description:QuantSeq from MCF-7, U2OS, and RPE-1 cells treated with Nutlin-3a or DMSO control

2024-09-18 | GSE223513 | GEO

CAGE-seq from Nutlin-3a-treated MCF-7, U2OS, and RPE-1 cells

Project description:CAGE-seq from MCF-7, U2OS, and RPE-1 cells treated with Nutlin-3a or DMSO control

2024-09-18 | GSE223512 | GEO

TMT-MS of PCIF1 siRNAs treated RPE-1 cells

Project description:RPE-1 cells treated with the indicated siRNAs for 48 h were subjected to the tandem mass tag quantitative proteomics analysis.Carry out relative protein quantification analysis using tandem mass tag mass spectrometry in RPE-1 cells to investigate the mechanism underlying PCIF1 attenuates ciliation.

2024-03-21 | PXD044338 | Pride

Nutlin-3a induced changes in the transcriptome of HCT116 and RPE-1 cells

Project description:RNA-seq from HCT116 and RPE-1 hTERT cells treated with Nutlin-3a or DMSO control

2024-09-18 | GSE216720 | GEO

Transcriptomic analysis of corticosteroids-treated hiPSC-derived RPE cells

Project description:Transcriptomic analysis of corticosteroids-treated hiPSC-derived RPE cells

| PRJNA723495 | ENA

RNA-seq profiling of RPE reprogramming

Project description:The plasticity of the retinal pigment epithelium (RPE) has been observed during proliferative vitreoretinopathy (PVR), a defective repair process in humans. In contrast, in the embryonic chick, the RPE can be efficiently reprogrammed to regenerate a complete neural retina after surgical removal and when supplied an exogenous source of FGF2. Here, we analyzed discrete RPE cell populations during early times of transiently reprogrammed (RPE 6 hours post-retinectomy) and reprogrammed (RPE 6 hours post-retinectomy and FGF2 treatment) cells, using laser capture microdissection followed by RNA sequencing (LCM-seq) and computational analysis.

2021-07-02 | GSE157129 | GEO

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