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N6-adenosine Methylation of Enhancer RNAs and YTHDC1 Facilitate Transcriptional Condensate Formation and 3D Chromatin Organization

ABSTRACT: N6-adenosine Methylation of Enhancer RNAs and YTHDC1 Facilitate Transcriptional Condensate Formation and 3D Chromatin Organization

PROVIDER: PRJNA600511 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10870326_1.fastq.gz	Fastqsanger.gz
	SRR10870326_2.fastq.gz	Fastqsanger.gz
	SRR10870327_1.fastq.gz	Fastqsanger.gz
	SRR10870327_2.fastq.gz	Fastqsanger.gz
	SRR10870328_1.fastq.gz	Fastqsanger.gz

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N6-adenosine Methylation of Enhancer RNAs and YTHDC1 Facilitate Transcriptional Condensate Formation and 3D Chromatin Organization

Project description:Eukaryotic chromatin is pervasively transcribed into nascent RNAs. However, a mechanistic understanding of their general roles remains lacking. Here, we characterized the landscapes of N6-adenosine methylation (i.e. m6A) on nascent RNAs using a new method that we referred to as MINT-Seq. We found widespread m6A deposition on nascent RNAs produced from regulatory elements including enhancer RNAs (eRNAs) and promoter upstream antisense RNAs (uaRNAs).

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