Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression levels of genes of in vitro generated Th1 and Th17 cells from OT-II and OT-II x NKG2D-/- mice

ABSTRACT: Expression levels of genes of in vitro generated Th1 and Th17 cells from OT-II and OT-II x NKG2D-/- mice

PROVIDER: PRJNA600875 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10876200.fastq.gz	Fastqsanger.gz
	SRR10876200_1.fastq.gz	Fastqsanger.gz
	SRR10876200_2.fastq.gz	Fastqsanger.gz
	SRR10876201.fastq.gz	Fastqsanger.gz
	SRR10876201_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Expression levels of genes of in vitro generated Th1 and Th17 cells from OT-II and OT-II x NKG2D-/- mice

Project description:We performed RNA-Seq and compared expression levels of genes of NKG2D+ OT-II Th1 or Th17 cells to OT-II x NKG2D-/- Th1 and Th17 cells, respectively.

2020-05-15 | GSE143522 | GEO

NKG2D

Project description:Macaca mulatta NKG2D, NKG2D protein [Source:NCBI gene (formerly Entrezgene);Acc:574240], is expressed in 3 baseline experiment(s);

| ENSMMUG00000018305 | ExpressionAtlas

TH1

Project description:Drosophila melanogaster TH1, TH1, is differentially expressed in 9 experiment(s);

| FBgn0010416 | ExpressionAtlas

TH1

Project description:Drosophila melanogaster TH1, TH1, is expressed in 3 baseline experiment(s);

| FBgn0010416 | ExpressionAtlas

OT-II T cells derived from uninfected or N.b. infected hosts transferred into congenic recipient post immunization

Project description:The goal was to determine changes in transcription in OT-II T cells post activation if pre-conditioned in a helminth-infected host

2024-08-02 | GSE221474 | GEO

The antitumor function of Th17-derived Th1 cell is better than traditional Th1 and Th17 cells

Project description:Th17 cells have better stemness and differentiation potential, and under certain circumstances, they can be stimulated to differentiate into other subcelltypes including Th1 and Treg. Here, we report that compared to traditional Th1 and Th17 cells, Th17-derived Th1 cells had greater anti-tumor activity. Both C57 mice ACT therapy and CAR-T therapy models were used to validate it. Mechanism: Th17-derived Th1 cells are able to express Th1 effector molecules as well as retain a lower level of exhaustion than Th1 cells. Additionally, it has a higher amount of type 1 interferon response and a stronger capacity for migration. Our research offers a fresh perspective on how ACT therapy and CAR-T therapy might develop in the future.

2024-10-31 | GSE276409 | GEO

RNA-sequencing of BCL6-sufficient and -insufficient OT-II TFH cells

Project description:We analyzed the transcriptome differences of BCL6-sufficient (CD4-Cre) and -insufficient (CD4-CrexBcl6fl/+) OT-II TFH cells. CD4-CrexBcl6fl/+ or control CD4-Cre OT-II T cells were transferred into CD45.1 Sap-/- mice. At day 3 post NP-OVA immunization, CXCR5hiPD-1hi TFH cells were sort-purified from the draining lymph node and prepared for RNA-seq analysis. Two technical repeats of ~200 cells per sample from each of 3 mice were included. BCL6-insufficient TFH cells differentially expressed many genes; among those downregulated were Stim1 and Plcg1, which code for STIM1 and PLCg1, respectively, that both impinge on calcium signaling downstream of TCR activation. Moreover, KEGG pathway analyses revealed that the calcium signaling-related pathway was generally upregulated in wildtype as compared to BCL6-insufficient TFH cells. These data support the notion that BCL6 control follicular T-B interactions by regulating multiple target genes involved in antigen-triggered calcium signaling in T cells.

2021-07-30 | GSE180924 | GEO

TH1

Project description:Arabidopsis thaliana TH1, Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic [Source:UniProtKB/Swiss-Prot;Acc:Q5M731], is differentially expressed in 54 experiment(s);

| AT1G22940 | ExpressionAtlas

TH1

Project description:Arabidopsis thaliana TH1, Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic [Source:UniProtKB/Swiss-Prot;Acc:Q5M731], is expressed in 15 baseline experiment(s);

| AT1G22940 | ExpressionAtlas

Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells.

Project description:T-helper cells are differentiated from CD4+ T cells and are traditionally characterized by inflammatory or immunosuppressive responses in contrast to cytotoxic CD8+ T cells. Mass-spectrometry studies on T-helper cells are rare. In this study, we aimed to identify the proteomes of human Th1 and Th1/Th17 clones derived from intestinal biopsies of Crohn's disease patients and to identify differentially expressed proteins between the two phenotypes. Crohn's disease is an inflammatory bowel disease, with predominantly Th1- and Th17-mediated response where cells of the "mixed" phenotype Th1/Th17 have also been commonly found. High-resolution mass spectrometry was used for protein identification and quantitation. In total, we identified 7401 proteins from Th1 and Th1/Th17 clones, where 334 proteins were differentially expressed. Major differences were observed in cytotoxic proteins that were overrepresented in the Th1 clones. The findings were validated by flow cytometry analyses using staining with anti-granzyme B and anti-perforin and by a degranulation assay, confirming higher cytotoxic features of Th1 compared with Th1/Th17 clones. By testing a larger panel of T-helper cell clones from seven different Crohn's disease patients, we concluded that only a subgroup of the Th1 cell clones had cytotoxic features, and these expressed the surface markers T-cell-specific surface glycoprotein CD28 and were negative for expression of natural killer group 2 member D.

| S-EPMC4813684 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data