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Effect of plasma from western diet fed mice on bone marrow derived macrophages (BMDM)

ABSTRACT: Effect of plasma from western diet fed mice on bone marrow derived macrophages (BMDM)

PROVIDER: PRJNA600895 | ENA |

REPOSITORIES: ENA

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Effect of plasma from western diet fed mice on bone marrow derived macrophages (BMDM)

Project description:Due to their ligand profiles, it can be hypothesized that Stab1 and Stab2 may be involved in atherosclerosis. We treated bone marrow derived macrophages (BMDM) with plasma from Stabilin-deficient and Wildtype mice to account for gene changes. We used microarrays to detail the global programme of gene expression in BMDM during different plasma treatments. We identified distinct classes of up- and down-regulated genes in response to the treatment.

2022-06-01 | GSE143533 | GEO

Effect of plasma from western diet fed mice on mouse aorta endothelial cells (MAOEC)

Project description:Effect of plasma from western diet fed mice on mouse aorta endothelial cells (MAOEC)

| PRJNA599126 | ENA

Expression data from Control diet, Western diet and Western diet + DHA fed rats.

Project description:LV hypertrophy is associated with Western diet consumption, while intake of n-3 polyunsaturated fatty acids is associated with anti-hypertrophic effects. We treated rats for 12 weeks with either a Control diet, a Western diet or a Western + DHA diet. For each of the 3 dietary treatments there were 2 pooled samples of heart tissue (with each pooled sample representing 5 rats) for a total of 6 arrays. Microarray analysis identified 66 differentially expressed transcripts. Pathways were identified using Ingenuity and DAVID software. Array results from two pooled samples (5 rats in each pool) for n=10 per treatment group were used for comparisons. Comparisons between Western vs. Control, Western + DHA vs. Control and Western + DHA vs. Western diets was subjected to analysis to generate log fold changes. A dietary treatment of 12 weeks was used in an effort to produce LVH while limiting the development of comorbidities. Microarray analysis was performed on pooled samples, followed by qRT-PCR and Western blot analysis. Groups were Control, Western and Western + DHA. Comparisons between groups are expressed as LogFC (i.e. LogFC_WESvCTRL, LogFC_DHAVCTRL, LogFC_DHAvWES), available in Series supplementary files.

2013-11-22 | E-GEOD-52603 | biostudies-arrayexpress

Expression data from Control diet, Western diet and Western diet + DHA fed rats.

2013-11-22 | GSE52603 | GEO

Changes in hepatic transcriptome profile in α4β7 mAb-treated Western diet-fed mice

Project description:Hepatic transcriptome of junctional adhesion molecule A knockout, F11r–/– mice fed a Western diet (WD) for eight weeks. A cohort of WD-fed mice were treated with IgG or α4β7 mAb for four weeks starting at week four following initiation of the WD.

2022-04-21 | GSE149208 | GEO

Renal Proximal Tubule Cell-specific Megalin Deletion Induces Tubulointerstitial Nephritis in Mice Fed Western Diet

Project description:Pharmacological inhibition of megalin (also known as low-density lipoprotein receptor-related protein 2: LRP2) attenuates atherosclerosis in hypercholesterolemic mice. Since megalin is abundant in renal proximal tubule cells (PTCs), PTC-LRP2 +/+ and -/- littermates in an LDL receptor -/- background were generated and fed a Western diet to determine effects of PTC-derived megalin on atherosclerosis. PTC-specific megalin deletion did not attenuate atherosclerosis in LDL receptor -/- mice in either sex. Serendipitously, we discovered that PTC-specific megalin deletion led to interstitial infiltration of CD68+ cells and tubular atrophy. The pathology was only evident in male PTC-LRP2 -/- mice fed the Western diet, but not in mice fed a normal laboratory diet. Renal pathologies were also observed in male PTC-LRP2 -/- mice in an LDL receptor +/+ background fed the same Western diet, demonstrating that the renal pathologies were dependent on diet and not hypercholesterolemia. By contrast, female PTC-LRP2 -/- mice had no apparent renal pathologies. In vivo multiphoton microscopy demonstrated that PTC-specific megalin deletion dramatically diminished albumin accumulation in PTCs within 10 days of Western diet feeding. RNA sequencing analyses demonstrated the upregulation of inflammation-related pathways in kidney. Overall, PTC-specific megalin deletion leads to tubulointerstitial nephritis in mice fed Western diet, with severe pathologies in male mice.

2024-07-04 | GSE268879 | GEO

Effect of beta3-adrenergic stimulation on liver gene expression in mice fed either a control diet or a western diet

Project description:The effect of beta3-adrenegic stimulation on liver gene expression was assessed in male mice after they had previously been fed a control diet or a western diet for 13 weeks. Mice fed the control diet were healthy. Mice fed the western diet became obese. Beta 3 adrenergic stimulation was achieved by using Beta 3 adrenergic receptor (CL316243). Overall, this experiment allowed us to investigate the effect of Beta3-adrenergic stimulation on liver gene expression in healthy mice and in obese mice.

2025-09-03 | GSE279895 | GEO

Effect of beta3-adrenergic stimulation on brown adipose tissue gene expression in mice fed either a control diet or a western diet

Project description:The effect of beta3-adrenegic stimulation on brown adipose tissue gene expression was assessed in male mice after they had previously been fed a control diet or a western diet for 13 weeks. Mice fed the control diet were healthy. Mice fed the western diet became obese. Beta 3 adrenergic stimulation was achieved by using Beta 3 adrenergic receptor (CL316243). Overall, this experiment allowed us to investigate the effect of Beta3-adrenergic stimulation on brown adipose tissue gene expression in healthy mice and in obese mice.

2025-09-03 | GSE279897 | GEO

Effect of thermoneutral housing (as compared to room temparture) on liver gene expression in mice fed a control diet or a western diet

Project description:Liver gene expression was assessed in male mice after they had previously been fed a control diet or a western diet for 13 weeks. Mice fed the control diet were healthy. Mice fed the western diet became obese. In each diet, half of the mice were housed at room temperature (22°C) and the other half was housed at thermoneutrality (30°C). Overall, this experiment allowed us to investigate the effect of housing temperature on liver gene expression in healthy mice and in obese mice.

2025-09-03 | GSE280075 | GEO

Effect of depletion of TAS1R3 on testicular gene expression in mice fed long-term western diet

Project description:Recent studies suggest that the western diet negatively affects male reproduction, but few underlying molecular mechanisms have been established. Also, several studies have reported TAS1R3 is expressed in testis, epididymis and sperm, but their role in male reproduction remains unknown. To investigate the function of taste receptor TAS1R3 in the male reproductive function under western diet condition, we performed RNA-sequencing analysis on testes from C57BL/6 mice fed long-term (18 weeks) western diet.

2024-12-19 | GSE221433 | GEO

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