Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Multi-drug Resistant Gram-negative Bacteria - CCHE57357

PROVIDER: PRJNA603448 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10973523_1.fastq.gz	Fastqsanger.gz
	SRR10973523_2.fastq.gz	Fastqsanger.gz
	SRR10973524_1.fastq.gz	Fastqsanger.gz
	SRR10973524_2.fastq.gz	Fastqsanger.gz
	SRR10973525_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 42

Similar Datasets

Project description:Raw sequence reads of multi-drug resistant Gram-negative bacteria causing bloodstream infections

| PRJNA1005941 | ENA

Bacteria

Project description:GCID Multi-drug resistant Gram-negative clinical isolates from Thailand

| PRJNA389557 | ENA

G-quadruplex DNA as a target for pathogenic bacteria: efficacy of an extended naphthalene diimide ligand and mode of action

Project description:Guanidine DNA quadruplex (G4-DNA) structures convey a distinctive layer of epigenetic information that is critical for the regulation of key biological activities and processes as genome transcription regulation, replication and repair. Despite several works that have been published recently, the information regarding their role and possible use as therapeutic drug targets in bacteria is still scarce. Here, we tested the biological activity of a small G4-DNA ligand library based on the naphthalene diimide (NDI) pharmacophore, against both Gram-positive and Gram-negative bacteria. For the best compound identified, NDI-10, the action mechanism was further characterized. Gram-negative bacteria were more resistant altogether due to the presence of the outer membrane, although the activity of the G4-Ligand was generally bactericidal, while it was bacteriostatic for Gram-positive bacteria. This asymmetric activity could be related to the different prevalence of putative G4-DNA structures in each group, the influence that they can exert on the gene expression (which was found more severe for the Gram-negative bacteria) and the role of the G4 structures in these bacteria, that seems to be more related to promote transcription in Gram-positive bacteria and repress transcription in Gram-negative.

2022-12-10 | GSE178890 | GEO

Project description:Multidrug-resistant Gram-negative bacteria

| PRJNA438531 | ENA

Project description:Genomic Analysis of Multi-Drug Resistant Gram-Negative Bacteria from Clinical Sources in Accra-Ghana

| PRJNA851374 | ENA

Treatment_of_multi_drug_resistant_Gram_negative_bacterial_infections_using_capsule_depolymerases

Project description:Treatment of multi drug resistant Gram negative bacterial infections using capsule depolymerases

| PRJEB19226 | ENA

Pseudomonas aeruginosa strain:XM8 | isolate:XM8

Project description:multi-drug resistant bacteria gemone

| PRJNA1025935 | ENA

A Dual-Mechanism Luminescent Antibiotic for Bacterial Infection Identification and Eradication

Project description:Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover antibacterial agents. Herein, we design and synthesize a compound of TPA2PyBu that kills both Gram-negative and Gram-positive bacteria with an undetectably low drug resistance. Comprehensive analyses reveal that the antimicrobial activity of TPA2PyBu proceeds via a unique dual mechanism by damaging bacterial membrane integrity and inducing DNA aggregation. TPA2PyBu could provide imaging specificity that differentiates bacterial infection from inflammation and cancer. Importantly, high in vivo treatment efficacy of TPA2PyBu was achieved in methicillin-resistant S. aureus infection mouse models. This promising antimicrobial agent suggests that combining multiple mechanisms of action into a single molecule can be an effective approach to address challenging bacterial infections.

2025-04-16 | GSE285871 | GEO

Project description:Genomic Characterization of Carbapenem-Resistant Gram-Negative bacteria

| PRJNA1368657 | ENA

Halobacteriovorax marinus SJ strain:SJ

Project description:A gram-negative bacteria which parasitizes other gram-negative bacteria.

| PRJNA12622 | ENA