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Distinct signature, origin and dynamics of macrophages in the peripheral and central nervous system (bulk)

ABSTRACT: Distinct signature, origin and dynamics of macrophages in the peripheral and central nervous system (bulk)

PROVIDER: PRJNA604614 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11007833.fastq.gz	Fastqsanger.gz
	SRR11007834.fastq.gz	Fastqsanger.gz
	SRR11007835.fastq.gz	Fastqsanger.gz
	SRR11007836.fastq.gz	Fastqsanger.gz
	SRR11007837.fastq.gz	Fastqsanger.gz

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Distinct signature, origin and dynamics of macrophages in the peripheral and central nervous system (bulk)

Project description:We performed ontogenic, transcriptomic and spatial characterization of sciatic nerve Macs (snMacs). Using multiple fate-mapping systems, we show that snMacs do not derive from the early embryonic precursors colonizing the CNS, but originate primarily from late embryonic precursors and get replaced by bone marrow-derived Macs over time. Using single-cell profiling, we identified a tissue-specific core signature of snMacs and found two spatially-separated snMacs: Relmα + Mgl1 + snMacs in the epineurium and Relmα Mgl1 snMacs in the endoneurium. Globally, snMacs lack most core signature genes of microglia, with only the endoneurial subset expressing a restricted number of these genes. Single-cell transcriptomics revealed that in response to injury both snMacs respond differently and that the PNS, in contrast to the CNS, is permissive to prolonged engraftment of monocyte-derived Macs recruited upon injury.

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