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DAZL targets in undifferentiated spermatogonia

ABSTRACT: DAZL targets in undifferentiated spermatogonia

PROVIDER: PRJNA605338 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11040384.fastq.gz	Fastqsanger.gz
	SRR11040385.fastq.gz	Fastqsanger.gz
	SRR11040386.fastq.gz	Fastqsanger.gz
	SRR11040387.fastq.gz	Fastqsanger.gz
	SRR11040388.fastq.gz	Fastqsanger.gz

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DAZL targets in undifferentiated spermatogonia

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Project description:Sustained spermatogenesis in adult males and recovery of fertility following germ cell depletion are dependent on undifferentiated spermatogonia with self-renewal potential. We have previously demonstrated a critical role for the transcription factor Spalt-like 4 (SALL4) in spermatogonial differentiation. However, it remains unclear whether SALL4 has broader roles within the spermatogonial pool despite its ability to co-regulate genes with PLZF, a transcription factor required for undifferentiated cell maintenance. To identify genes regulated by SALL4 in the male germline, we established cultures of undifferentiated spermatogonia from a Sall4 inducible knockout mouse model. Cells were treated with vehicle (as control) or tamoxifen to induce gene deletion, then cells harvested and analysed by microarray to identify genes mis-expressed upon loss of SALL4.

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