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Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model

ABSTRACT: Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model

PROVIDER: PRJNA606607 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11085442_1.fastq.gz	Fastqsanger.gz
	SRR11085442_2.fastq.gz	Fastqsanger.gz
	SRR11085443_1.fastq.gz	Fastqsanger.gz
	SRR11085443_2.fastq.gz	Fastqsanger.gz
	SRR11085444_1.fastq.gz	Fastqsanger.gz

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Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model

Project description:We have investigated Amblyomin-X-treated horse melanomas to better understand its mode of action through transcriptome analysis and also the in vivo model. Amblyomin-X is a Kunitz-type homologous protein that selectively leads to the death of tumor cells via ER stress and apoptosis, currently under investigation as a new drug candidate for cancer treatment. Melanomas are immunogenic tumors, and a better understanding of the immune responses are warranted. Equine melanomas are spontaneous and not aggressive as human melanomas are, and we showed that the in vivo treatment of encapsulated horse melanoma tumors led to a significant tumor size reduction or even the complete disappearance of the tumor mass through intratumoral injections of Amblyomin-X. Transcriptome analysis identified ER and mitochondria-stresses, modulation of the innate immune system, apoptosis, and possibly immunogenic cell death activation. Interactome analysis showed that Amblyomin-X potentially interacts with key elements found in transcriptomics. Taken together, Amblyomin-X modulated the tumor immune microenvironment in different ways, making at least part to induce tumor cell death.

2020-04-22 | GSE145292 | GEO

Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model.

Project description: Not available

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Gene expression variation in horse placental and fetal tissue, and resting and stimulated horse lymphocytes [Agilent-018932]

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Gene expression variation in horse placental tissue, and resting and stimulated horse lymphocytes [Agilent-021322]

Project description:We undertook gene expression microarray experiments to identify genes that are differentially expressed in invasive (Chorionic Girdle) and non-invasive (Chorion) placental tissue, and resting and Pokeweed Mitogen (PWM) stimulated horse lymphocytes. Conceptus tissues were dissected to obtain chorionic girdle, and chorion. Freshly isolated horse peripheral blood lymphocytes were split and harvested immediately, or stimulated with PWM and harvested over a five day period. These experiments utilized a commercially available Agilent horse array that featured >43,000 probes on a 4x44k array format.

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Genome-wide SNP data of Chinese indigenous horse breed (Jinjinag horse samples)

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Genome-wide SNP data of Chinese indigenous horse breed (additional horse samples)

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Gene expression variation in horse placental and fetal tissue, and resting and stimulated horse lymphocytes

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Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death

Project description:Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death

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