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Pangolin coronavirus

ABSTRACT: Pangolin coronavirus Raw sequence reads

PROVIDER: PRJNA606875 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR11093265.fastq.gz	Fastqsanger.gz
	SRR11093266.fastq.gz	Fastqsanger.gz
	SRR11093267.fastq.gz	Fastqsanger.gz
	SRR11093268.fastq.gz	Fastqsanger.gz
	SRR11093269.fastq.gz	Fastqsanger.gz

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Project description:The natural host of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains elusive. A panel of SARS-CoV-2-related coronaviruses have been identified in pangolins, while the infectivity and pathogenicity of these pangolin-origin coronaviruses (pCoV) to human remains largely unknown. Herein, we comprehensively characterized the infectivity and pathogenicity of pCoV-GD01, the most closest pCoV to SARS-CoV-2, in human cells, human tracheal epithelium organoids, and established animal models in comparision with. The results show that pCoV-GD01 showed similar infectivity to SARS-CoV-2 in human cells and organoids. Remarkably, intranasal inoculation of pCoV-GD01 caused severe lung pathological damage in hACE2 mice, and could establish efficient transmission among co-caged hamsters. Interestingly, in-depth antigenic analysis and animal heterologous challenge experiments demonstrate that pre-existing immunity induced by SARS-CoV-2 infection or vaccination was sufficient to provide cross-protection against pCoV-GD01 challenge. These collective results highlight the potential risk of persistent spillover from animal hosts like the pangolin, and the COVID-19 pandemic and massive vaccination have reduced the possibility of pCoVs circulation in mankind.

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