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DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ChIPseq]

ABSTRACT: DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ChIPseq]

PROVIDER: PRJNA607517 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11112573.fastq.gz	Fastqsanger.gz
	SRR11112574.fastq.gz	Fastqsanger.gz
	SRR11112575.fastq.gz	Fastqsanger.gz
	SRR11112576.fastq.gz	Fastqsanger.gz

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DNA G-quadruplexes modulate highly transcribed genes in human chromatin

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DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ChIPseq]

Project description:G4s are nucleic acids secondary structures that form in the presence of four or more runs of gunanine. In vitro results suggested that G4s are involved in the regulation of both transcription and replication processes. In vitro results suggested that G4s are involved in the regulation of both transcription 6–10 and replication 11–13 processes allowed to demonstrate the actual folding of G4s in live cells, but also inserted them in a more biologically relevant context. . In the present work we mapped G4s in the chromatin of a WD-LPS cell line (93T449), we integrated the information of G4 folding with their chromatin context, the transcriptional level of the associated genes and compared the results with data obtained in a cell line of different origin (HaCaT).

2021-04-26 | GSE145535 | GEO

DNA G-quadruplexes modulate highly transcribed genes in human chromatin

Project description:This SuperSeries is composed of the SubSeries listed below.

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DNA G-quadruplexes modulate highly transcribed genes in human chromatin [ATAC-seq]

2021-04-26 | GSE145532 | GEO

DNA G-quadruplexes modulate highly transcribed genes in human chromatin [RNA-seq]

2021-04-26 | GSE145537 | GEO

Sumoylation regulates general transcription factors at promoters of highly transcribed genes

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Condensin mediates the chromosomal clustering of highly transcribed genes in bacteria

Project description:Purpose: Study MukB, RNAP, TopA, and ParC binding profiles on E.coli chromosome. Methods: We constructed affinity tagged MukB, ParC, and TopA strains, and immunoprecipitated using anti-FLAG antibodies as well as an RNAP primary antibody. Results: MukB, RNAP, TopA, and ParC were all bound to rDNAs on the coding sequences, as well as the coding regions of 244 highly transcribed genes, including tRNAs, genes coding for ribosomal proteins, housekeeping genes (for example, atpA and rpoB), as well as OriC. Conclusions: We found that the bacterial condensin, MukB, is recruited to actively transcribed genes such as rDNA through transcription induced supercoiling.

2015-05-29 | GSE69250 | GEO

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