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Analysis of gene expression change between ectopic expression SOX2 in T24 bladder cancer cells.

ABSTRACT: Analysis of gene expression change between ectopic expression SOX2 in T24 bladder cancer cells.

PROVIDER: PRJNA608459 | ENA |

REPOSITORIES: ENA

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Analysis of gene expression change between ectopic expression SOX2 in T24 bladder cancer cells.

Project description:We collected total RNA from both T24-Ctrl and T24-SOX2 and examined mRNA expression profile, comprehensively.

2020-02-25 | GSE145826 | GEO

Differential Gene Expression between Chemoresistant and Chemosensitive T24 Human Bladder Cancer Cells

Project description:This project employed proteomics to analyze protein expression profiles between chemoresistant and chemosensitive variants of the human bladder cancer T24 cell line. The objective was to identify key differentially expressed proteins and their associated signaling pathways involved in chemotherapy resistance. The findings aim to provide new insights and potential therapeutic targets for overcoming chemoresistance in bladder cancer.

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Project description:We knocked down SOX4 in T24 cell and created 3 cell lines: T24-scrambled, T24-SOX4-knockdown and T24-SOX4-rescue and compared gene expression changes SOX4 is a developmental transcription factor that is overexpressed in as many as 23% of bladder cancer patients, but the role of SOX4 in bladder cancer tumorigenesis is not well understood. Given SOX4’s many roles in embryonic development and context-dependent regulation of gene expression, we sought to understand SOX4’s contribution to bladder cancer and to elucidate SOX4 regulated genes that might contribute to tumorigenesis. We employed a CRISPR interference (CRISPRi) method to transcriptionally repress SOX4 expression in T24 bladder cancer cell lines, rescued these cell lines with lentivirally expressed SOX4, and performed whole genome expression profiling. SOX4 knockdown cells exhibited decreased invasive capabilities but no changes in migration or proliferation, while rescue with SOX4 lentiviral vector restored the invasive phenotype. Gene expression profiling revealed 173 high confidence SOX4 regulated genes

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