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Gene expression profiling on heads of Drosophila chromodomain helicase DNA binding protein 1 (CHD1) deletion mutants

ABSTRACT: Gene expression profiling on heads of Drosophila chromodomain helicase DNA binding protein 1 (CHD1) deletion mutants

PROVIDER: PRJNA610298 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11237854.fastq.gz	Fastqsanger.gz
	SRR11237855.fastq.gz	Fastqsanger.gz
	SRR11237856.fastq.gz	Fastqsanger.gz
	SRR11237857.fastq.gz	Fastqsanger.gz
	SRR11237858.fastq.gz	Fastqsanger.gz

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Gene expression profiling on heads of Drosophila chromodomain helicase DNA binding protein 1 (CHD1) deletion mutants

Project description:CHD1 is a conserved ATP-dependent chromatin remodeling factor with roles in transcriptional regulation and chromatin assembly. Here we show that deletion of Chd1 causes multiple behavioral and metabolic defects. In particular, it diminishes food-intake and results in shortened lifespan of mutant flies. These phenotypes can be rescued by brain-specific expression of Chd1 via the elav promoter. Consistently, neuron-specific expression of Chd1 rescues the wide-spread transcriptional dysregulation observed in the absence of CHD1.

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CHD1_RIME - CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis

Project description:Crosslinked chromatin bound protein complexes were immunopurified, digested, and analyzed by mass spectrometry to identify and quantify proteins associate with the chromodomain helicase (Chd1).

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Project description:Drosophila melanogaster Chd1, Chromodomain-helicase-DNA-binding protein 1, is expressed in 5 baseline experiment(s);

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CHD1 Loss Hijacks SREBP2-mediated Cholesterol Biosynthesis to Fuel SPOP-deficient Prostate Cancer and Confers Resistance to Castration

Project description:Androgen receptor (AR) is an important driver in the disease progression of castration-resistant prostate cancer (CRPC). Speckle-type BTB/POZ protein (SPOP) mutations stabilize AR and frequently co-occur with the loss of chromodomain helicase DNA-binding protein 1 (CHD1). We generated a new genetically engineered mouse model and prostate cancer cells model containing CHD1 deletion and SPOP mutation to study the underlying mechanism. We found CHD1 loss–induced cholesterol production supplies intratumoral androgen biosynthesis and retains AR transcriptional activity in SPOP-mutated prostate tumors, leading to castration resistance.

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Project description:Rattus norvegicus Chd1, chromodomain helicase DNA binding protein 1 [Source:RGD Symbol;Acc:1306794], is differentially expressed in 23 experiment(s);

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Project description:Rattus norvegicus Chd1, chromodomain helicase DNA binding protein 1 [Source:RGD Symbol;Acc:1306794], is expressed in 5 baseline experiment(s);

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