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Examining changes in the chromosomal interaction network in replicative senescent, rapamycin treatment, and p65 inhibition

ABSTRACT: Examining changes in the chromosomal interaction network in replicative senescent, rapamycin treatment, and p65 inhibition

PROVIDER: PRJNA610882 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR11256074_1.fastq.gz	Fastqsanger.gz
	SRR11256074_2.fastq.gz	Fastqsanger.gz
	SRR11256075_1.fastq.gz	Fastqsanger.gz
	SRR11256075_2.fastq.gz	Fastqsanger.gz

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Examining changes in the chromosomal interaction network in replicative senescent, rapamycin treatment, and p65 inhibition

Project description:Analysis of HiC genome wide chromosomal interaction data in the context of replicative senescence, rapamycin treatment, the withdrawal of rapamycin, and with p65 inhibition in rapamycin withdrawal. This was done in order to determine what changes in chromosomal architecture occur during replicative senescence, and what impact rapamycin treatment or withdrawal or p65 inhibition has upon these changes.

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MicroRNA signature of young and replicative senescent human umbilical vein endothelial cells (HUVECs)

Project description:MicroRNAs regulate various cellular processes. While several genes associated with replicative senescence have been described in endothelial cells, miRNAs that regulate these genes remain largely unknown. The present study was designed to identify miRNAs associated with replicative senescence and their target genes in HUVECs. We have employed Agilent Human MicroRNAs microarray platform to evaluate the expressions of 866 human miRNAs and 89 human viral miRNAs, based on Sanger miRNA database release 12.0 miRNA expression profiles were established for young and replicative senescent HUVECs

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Gene signature of young and replicative senescent human umbilical vein endothelial cells (HUVECs)

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Project description:ChIPs of the histone modifications H3K27ac and H3K4me2, which mark enhancers and promoters, were examined during the course of replicative senescence in BJ fibroblasts that were grown in the presence or absence of rapamycin.

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Project description:BJ Fibroblasts were maintained in rapamycin and were passaged until reaching growth arrest at very high passages. These cells were then maintained in or withdrawn from rapamycin, during which time they were given either control treatments or the p65 inhibitor TPCA-1.

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Project description:p65

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