Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

WGBS and RNA-seq of mouse livers and human Hep3B cells

ABSTRACT: WGBS and RNA-seq of mouse livers and human Hep3B cells

PROVIDER: PRJNA611987 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11290060_1.fastq.gz	Fastqsanger.gz
	SRR11290060_2.fastq.gz	Fastqsanger.gz
	SRR11290061_1.fastq.gz	Fastqsanger.gz
	SRR11290061_2.fastq.gz	Fastqsanger.gz
	SRR11290062_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

WGBS and RNA-seq of mouse livers and human Hep3B cells

Project description:We detected the contributions of CpG methylation in gene promoter to the expression of acute phase proteins in livers

2020-04-07 | GSE146797 | GEO

Mouse preimplantation imprinting [WGBS]

Project description:Mouse preimplantation imprinting [WGBS]

| PRJNA638354 | ENA

Human hepatocyte metaplasia in injured humanized mouse livers

Project description:Human hepatocyte metaplasia in injured humanized mouse livers

| PRJNA253143 | ENA

Comparison of Protein Expressions of Drug-Metabolizing Enzymes between Human Liver and the Hepatic Cell Lines HepG2, Hep3B and Huh7 using SWATH and MRM-HR Proteomics

Project description:Human hepatic cell lines have been widely used as an in vitro model for the study of drug metabolism and liver toxicity. However, the validity of this model is still a subject of debate because the expressions of various proteins including drug-metabolizing enzymes (DMEs) in the cell lines can differ significantly from that of human livers. In the present study, we first conducted an untargeted proteomics of the microsomes of the cell lines HepG2, Hep3B, and Huh7 in comparison with human livers using a SWATH method. Furthermore, a targeted proteomic approach, named high-resolution multiple reaction monitoring (MRM-HR), was utilized to compare the expressions of pre-selected DMEs between human livers and the cell lines.

2018-04-18 | PXD008190 | Pride

Differential gene expression in Hep3B and Hep3B SOX4-/- cells

Project description:Overexpression of SOX4 in various kinds of cancers specimen was associated with poor prognosis of patients; however, the role of SOX4 in angiogenesis or tumor microenvironment modulation remains unclear. Therefore the endogenous SOX4 was knockout and the differential gene expression between Hep3B and Hep3B SOX4-/- cells were examined via genechip. We found that the differentially expressed genes, EzH2, a SOX4-associated partner, and CXCL12, were repressed in Hep3B SOX4-/- cells compared with parental Hep3B; these results were further assessed via qRT-PCR in Hep3B SOX4-/- versus Hep3B cells.

2020-12-01 | GSE141909 | GEO

Expression data of hepatocytes isolated from chimeric mouse livers repopulated with human hepatocytes and from normal human livers

2012-11-27 | GSE33846 | GEO

Expression data of hepatocytes isolated from chimeric mouse livers repopulated with human hepatocytes and from normal human livers

Project description:Expression data of hepatocytes isolated from chimeric mouse livers repopulated with human hepatocytes and from normal human livers

| PRJNA148171 | ENA

Human liver cancer cells Hep3B: Valeric acid treated vs. Control

Project description:Transcriptional profiling of human liver cancer cells (Hep3B) treated with valeric acid compared to control.

2021-11-12 | GSE140280 | GEO

Expression data of hepatocytes isolated from chimeric mouse livers repopulated with human hepatocytes and from normal human livers

Project description:We generated chimeric mice with livers that were predominantly repopulated with human hepatocytes. Hepatocytes were isolated from the chimeric mouse livers and their gene expressions were compared with hepatocytes isolated from normal human livers . Cluster and principal components analyses showed that gene expression profiles of hepatocytes from the chimeric mice and those from normal human livers were extremely closed. Additionally, we performed microarray experiments to examine gene expression in human tissues. This data was used for comparison with hepatocytes. A total of 22 tissues (bone marrow, cerebellum, colon, cortex, fetal brain, heart, kidney, liver, lung, pancreas, prostate, salivary gland, skeletal muscle, small intestine, spinal cord, spleen, stomach, testes, thymus, thyroid, trachea and uterus) were examined. The chimeric mice were generated by transplantation of 2 different donor hepatocytes. Hepatocytes were isolated from the mouse livers and normal human livers, and their cDNAs were used for microarray analysis. Total RNA isolated from human tissues and cell cultures were labeled and hybridized to the GeneChip Human Genome U133 Plus 2.0 Array according to the manufacturer's protocol.

2012-11-27 | E-GEOD-33846 | biostudies-arrayexpress

Transcription profiling of human Hep3B cells transfected with L1CAM

Project description:To compare the transcription profiling between empty vector transfected Hep3B and L1CAM transfected Hep3B

2011-08-01 | E-MEXP-1357 | biostudies-arrayexpress